β-Nicotinamide adenine dinucleotide (ʻakika manuahi) (NAD)
ʻO NAD kahi coenzyme maʻamau o ka dehydrogenase i loko o nā meaola ola. Ke komo nei ia i nā hopena redox i loko o nā meaola ola, a lawe a hoʻoili i nā electrons no nā mea i loko o ka hopena. He kuleana koʻikoʻi ko Dehydrogenase i ka metabolism o ke kanaka. ʻAʻole hiki ke hana maʻamau kekahi mau neʻe metabolic kumu o ke kino o ke kanaka, e like me ka decomposition protein, ka decomposition carbohydrate, a me ka decomposition momona me ka ʻole o ka dehydrogenase, a e nalowale nā kānaka i nā hōʻailona koʻikoʻi. A no ka mea hiki i ka hui pū ʻana o NAD a me dehydrogenase ke hoʻoulu i ka metabolism, no laila he ʻāpana koʻikoʻi ʻo NAD o ke kino o ke kanaka. Wahi a ka hoʻohana ʻana i ka huahana, hiki ke hoʻokaʻawale ʻia i nā pae penei: biotransformation grade, diagnostic reagent grade, health food grade, API a me nā mea maka hoʻomākaukau.
| Inoa Kemika | ʻO Nicotinamide adenine dinucleotide (ʻakika manuahi) |
| Nā huaʻōlelo like | ʻO ka β-Nicotinamide adenine dinucleotide |
| Helu CAS | 53-84-9 |
| Kaumaha Molekala | 663.43 |
| Formula Molekala | C21H27N7O14P2 |
| EINECS号: | 200-184-4 |
| Kiko heheʻe | 140-142 °C (decomp) |
| mahana mālama | -20°C |
| ka hiki ke hoʻoheheʻe ʻia | H2O: 50 mg/mL |
| palapala | Pauka |
| kala | Keʻokeʻo |
| Merck | 14,6344 |
| BRN | 3584133 |
| Paʻa: | Paʻa. Hygroscopic. Kūlike ʻole me nā mea hoʻoheheʻe ikaika. |
| ʻInChIKy | BAWFJGJZGIEFAR-WWRWIPRPSA-N |
| Mea Hoʻāʻo | Nā kikoʻī |
| helehelena | Keʻokeʻo a i ka pauka kristal keʻokeʻo |
| Ka nānā ʻana o ka spectral UV εma 260 nm a me ka pH 7.5 | (18±1.0)×10³ L/mol/cm |
| Ka hiki ke hoʻoheheʻe ʻia | 25mg/mL 25mg/mL i loko o ka wai |
| ʻIkepili (ma o ka nānā ʻana o ka enzymatic me ADH ma ka pH 10, me ka hoʻohana ʻana i ka spectrophotometer, abs.340nm, ma ke kumu anhydrous) | ≥98.0% |
| Assay (e HPLC, ma ke kumu anhydrous) | 98.0~102.0% |
| Maʻemaʻe (e HPLC, % wahi) | ≥99.0% |
| Ka nui o ka wai (na KF) | ≤3% |
Pūʻolo:ʻŌmole, ʻeke pepa alumini, 25kg/Papa Kālā, a i ʻole e like me ke koi a ka mea kūʻai aku.
Kūlana Mālama:E mālama paʻa i kahi pani pouli, no ka mālama lōʻihi e mālama i ka 2~8℃.
Papa hoʻololi Bio: Hiki ke hoʻohana ʻia no ka synthesis biocatalytic o nā mea waena lāʻau lapaʻau a me nā API, ʻo ia hoʻi me nā enzymes catalytic, e like me ketoreductase (KRED), nitroreductase (NTR), P450 monooxygenase (CYP), formate dehydrogenase (FDH)), glucose dehydrogenase (GDH), a me nā mea ʻē aʻe, hiki ke hana pū e hoʻololi i nā ʻano waena amino acid like ʻole a me nā lāʻau lapaʻau ʻē aʻe e pili ana. I kēia manawa, ua hoʻomaka nā hale hana lāʻau lapaʻau kūloko he nui e hoʻopili i ka hoʻololi enzyme biological, a ke ulu wikiwiki nei ke koi mākeke no NAD+.
Papa reagent diagnostic: I hui pū ʻia me nā ʻano enzyme diagnostic like ʻole, e like me ka mea maka o nā pahu diagnostic.
Papa meaʻai olakino: ʻO NAD kahi coenzyme o ka dehydrogenase. He kuleana koʻikoʻi kona i ka glycolysis, gluconeogenesis, ke kaʻina hana waikawa tricarboxylic, a me ke kaulahao hanu, he kuleana koʻikoʻi kona i ka hana ʻana i ka ikehu, a kōkua i ka hana ʻana o L-dopa, ka mea e lilo i dopamine Neurotransmitters. ʻOi loa aku i nā makahiki i hala iho nei, ua ʻike ʻia ʻo ia ka "mīkini" a me ka "wahie" i ke kaʻina hana o ka hoʻoponopono ʻana i nā pōʻino cell. Wahi a ka noiʻi, ʻo ka hoʻohui ʻana o nā coenzymes (me NMN, NR, NAD, NADH) in vitro hiki ke hoʻonui i ka hiki ke antioxidant o nā cell kiko, kāohi i ka hōʻailona apoptosis, hoʻihoʻi i ka hana cell maʻamau, pale i ka hanana ʻana o ka maʻi a kāohi paha i ka holomua o ka maʻi.
Eia kekahi, hiki i nā coenzymes ke hoʻonui i ka hiki o ka pane ʻana o ka pale ʻana ma o ka hoʻoulu ʻana a me ka hoʻolaha ʻana i ka oʻo ʻana o nā cell immune innate, e hana ana i nā mea anti-inflammatory a me ke kāohi ʻana i nā cell T regulatory. ʻO Nicotinamide dinucleotide oxidation state (NAD+) kahi coenzyme i loaʻa i nā cell ola āpau. He kuleana koʻikoʻi ia i nā haneli o nā kaʻina hana metabolic i loko o nā cell, komo i nā tausani o nā hopena physiological, a ʻo ia ka lālā koʻikoʻi o ke kaulahao lawe electron. ʻO ka mea hāʻawi hydrogen; i ka manawa like, hana ʻo coenzyme I ma ke ʻano he substrate wale nō o nā enzymes pili i loko o ke kino, e kōkua ana i ka mālama ʻana i ka hana o nā enzymes.
ʻO Nicotinamide mononucleotide (NMN) ka hui mua o ka nicotinamide adenine dinucleotide oxidation state (NAD+), ka mea e pili ana i ka synthesis o NAD in vivo. I ka makahiki 2013, ua ʻike ʻo Polofesa David Sinclair o ke Kula Lapaʻau ʻo Harvard me ka makahiki, ke emi mau nei ka pae cofactor coenzyme I (NAD+) o ka protein lōʻihi i loko o ke kino, kahi e alakaʻi ai i ka emi ʻana o ka hana mitochondrial o ka "dynamo" o ke kelepona, e hoʻoulu ana i ka ʻelemakule, a me nā mea like ʻole i loko o ke kino. Pēlā i hana ʻia ai ka hana hewa o kēia ʻano hana. Wahi a kāna mau haʻawina, emi iho ka nui o NAD+ i loko o ke kino kanaka me ka makahiki, e hopena ana i ka wikiwiki o ka ʻelemakule mai ka makahiki 30, me nā wrinkles, ka hoʻomaha ʻana o nā ʻiʻo, ka hōʻiliʻili momona, a me nā maʻi e like me ka maʻi puʻuwai, ke koko kiʻekiʻe, ka hahau ʻana, ka maʻi diabetes a me ka maʻi Alzheimer i hoʻonui i ka pilikia. ʻO ke kī i ka lōʻihi o ka ola, ʻo ia ka hoʻonui ʻana i ka pae o ka coenzyme I (NAD+) i loko o ke kino, hoʻonui i ka wikiwiki o ka metabolism cell, a hoʻoulu i ka ikaika ʻōpio.
ʻO ka API a me nā mea maka hoʻomākaukau: Hoʻohana ʻia ʻo NAD+ i nā inikini no ka mālama ʻana/kaohi ʻana i ka hoʻohui lāʻau lapaʻau, me ka NAD IV intravenous therapy i hoʻokō ʻia ma ʻAmelika Hui Pū ʻIa, ʻEulopa, Rusia, ʻApelika Hema, Mekiko, ʻAmelika Hema, Hikina Hema ʻAsia a me nā ʻāina ʻē aʻe. ʻO nā huahana i hoʻomākaukau ponoʻī ʻia e ka lāʻau lapaʻau, e like me nā hale kūʻai lāʻau lapaʻau ʻAmelika, hiki ke kūʻai i nā mea maka no ka hāʻawi ʻana iā lākou iho, e like me nā hoʻomākaukau haukapila Kina, hoʻomalu ia i ka maikaʻi o nā mea maka iā ia iho, a hoʻomākaukau i nā hoʻomākaukau i nā lāʻau lapaʻau.
