β-Nicotinamide adenine dinucleotide (ʻakika manuahi) (NAD)
ʻO NAD kahi coenzyme maʻamau o dehydrogenase i nā mea ola.Ua komo i loko o redox reactions i loko o nā mea ola, a lawe a hoʻoili electrons no nā mea i loko o ka hopena.He kuleana koʻikoʻi ka Dehydrogenase i ka metabolism kanaka.ʻAʻole hiki ke hana maʻamau me ka ʻole o ka dehydrogenase, e like me ka decomposition protein, decomposition carbohydrate, a me ka momona momona, a e nalowale nā kānaka i nā hōʻailona koʻikoʻi.A no ka hui pū ʻana o NAD a me dehydrogenase hiki ke hoʻoikaika i ka metabolism, no laila ʻo NAD kahi ʻāpana koʻikoʻi o ke kino kanaka.Wahi a ka hoʻohana ʻana i ka huahana, hiki ke hoʻokaʻawale ʻia i nā māka aʻe: biotransformation grade, diagnostic reagent grade, health food grade, API a me ka hoʻomākaukau ʻana i nā mea maka.
| Inoa Kimia | Nicotinamide adenine dinucleotide (ʻakika manuahi) |
| Nā huaʻōlelo like | β-Nicotinamide adenine dinucleotide |
| Helu CAS | 53-84-9 |
| Kaumaha Molekala | 663.43 |
| ʻĀpana Molekala | C21H27N7O14P2 |
| EINECS号: | 200-184-4 |
| Lae hehee | 140-142 °C (decomp) |
| ka mahana mālama. | -20°C |
| hikiwawe | H2O: 50 mg/mL |
| ʻano | Pauda |
| kala kala | Keʻokeʻo |
| ʻO Merck | 14,6344 |
| BRN | 3584133 |
| Paʻa: | Paʻa.Hygroscopic.ʻAʻole kūpono me nā mea oxidizing ikaika. |
| InChIKey | BAWFJGJZGIEFAR-WWRWIPRPSA-N |
| Mea hoao | Nā kikoʻī |
| Ka nana aku | Keʻokeʻo a keʻokeʻo keʻokeʻo crystalline pauda |
| Ka nānā 'ana i nā hi'ohi'ona o UV εma 260 nm a me ka pH 7.5 | (18±1.0)×10³ L/mol/cm |
| Ka hikiwawe | 25mg/mL 25mg/mL i ka wai |
| Maʻiʻo (ma ka hoʻopalekana enzymatic me ADH ma ka pH 10, me ka hoʻohana ʻana i ka spectrophotometer, abs.340nm, ma ke kumu anhydrous) | ≥98.0% |
| ʻIke (e ka HPLC, ma ke kumu anhydrous) | 98.0~102.0% |
| Maʻemaʻe (e ka HPLC, %a) | ≥99.0% |
| Waiwai (na KF) | ≤3% |
Pūʻolo:ʻO ka ʻōmole, ʻeke ʻeke alumini, 25kg / pahu pahu pahu, a i ʻole e like me ka makemake o ka mea kūʻai aku.
Kūlana mālama:E hoʻopaʻa paʻa i ka pōʻeleʻele, no ka mālama lōʻihi e mālama ʻia ma 2 ~ 8 ℃.
Biotransformation grade: Hiki ke hoʻohana no ka biocatalytic synthesis o pharmaceutical intermediates a me APIs, nui me catalytic enzymes, e like me ketoreductase (KRED), nitroreductase (NTR), P450 monooxygenase (CYP), formate dehydrogenase (FDH) ), glucose dehydrogenase (). GDH), a me nā mea ʻē aʻe, hiki ke hui pū i ka hoʻololi ʻana i nā ʻano amino acid intermediates a me nā lāʻau lapaʻau e pili ana.I kēia manawa, ua hoʻomaka ka nui o nā ʻoihana lāʻau lapaʻau e hoʻopili i ka hoʻololi enzyme biological, a ke ulu wikiwiki nei ka mākeke no NAD +.
ʻO ka helu diagnostic reagent: Hoʻohui ʻia me nā ʻano enzyme diagnostic like ʻole, e like me ka mea maka o nā pahu diagnostic.
Papa meaʻai olakino: ʻO NAD kahi coenzyme o dehydrogenase.He hana koʻikoʻi ia i ka glycolysis, gluconeogenesis, ka tricarboxylic acid cycle, a me ke kaulahao hanu, he mea nui i ka hana ikehu, a kōkua i ka hana ʻana o L-dopa, i lilo i dopamine Neurotransmitters.ʻOi loa i nā makahiki i hala iho nei, ua ʻike ʻia ʻo ia ka "engine" a me ka "fuel" i ke kaʻina hana o ka hoʻoponopono ʻana i ka pōʻino cell.Wahi a ka noiʻi, hiki i ka hoʻohui ʻana o nā coenzymes (me NMN, NR, NAD, NADH) i loko o ka vitro ke hoʻonui i ka mana antioxidant o nā cell tissue, kaohi ʻana i ka hōʻailona apoptosis, hoʻihoʻi i ka hana maʻamau o ka cell, pale i ka maʻi a i ʻole ke kāohi i ka piʻi ʻana o ka maʻi.
Eia hou, hiki i nā coenzymes ke hoʻonui i ka hiki o ka pane immune ma o ka hoʻouluʻana a me ka hoʻouluʻana i ka maturation o nā pūnaewele immune innate, e hana ana i nā mea anti-inflammatory a me ka hoʻopauʻana i nā pūnaewele T regulatory. ʻO Nicotinamide dinucleotide oxidation state (NAD +) he coenzyme i loaʻa i nā pūnaewele ola a pau.He kuleana koʻikoʻi ia i nā haneli o nā kaʻina metabolic i loko o nā cell, komo i nā kaukani o nā hopena physiological, a ʻo ia ka lālā koʻikoʻi o ke kaulahao lawe electron.Hāʻawi i ka hydrogen;i ka manawa like, hana ʻo coenzyme I ma ke ʻano he substrate hoʻokahi o nā enzyme pili i loko o ke kino, e kōkua ana i ka mālama ʻana i ka hana o nā enzymes.
ʻO Nicotinamide mononucleotide (NMN) ka mea mua o ka nicotinamide adenine dinucleotide oxidation state (NAD +), i komo i ka synthesis o NAD i vivo.Ma 2013, ua ʻike ʻo Polofesa David Sinclair o ke Kula Lapaʻau ʻo Harvard me ka makahiki, ʻo ka cofactor coenzyme I (NAD +) pae o ka protein lōʻihi i loko o ke kino e hoʻomau i ka emi ʻana, e alakaʻi ana i ka emi ʻana o ka hana mitochondrial o ka "dynamo" o ke kelepona, e hoʻoulu ai i ka ʻelemakule. , a me na mea like ole o ke kino.Hoʻopuka ʻia ka hewa o kēia ʻano hana.Wahi a kāna mau haʻawina, ʻo ka ʻike o ka NAD + i ke kino o ke kanaka e emi iho ana me ka makahiki, e hopena i ka ʻelemakule wikiwiki mai ka makahiki 30, me nā wrinkles, hoʻomaha hoʻomaha ʻiʻo, hōʻiliʻili momona, a me nā maʻi e like me ka maʻi puʻuwai, ke koko kiʻekiʻe, ka hahau. , ka maʻi maʻi a me ka maʻi Alzheimer i hoʻonui i ka pilikia.ʻO ke kī i ka lōʻihi o ke ola ʻana ʻo ia ka hoʻonui ʻana i ke kiʻekiʻe o ka coenzyme I (NAD+) i loko o ke kino, hoʻonui i ka wikiwiki o ka metabolism cell, a hoʻoulu i ka ikaika o ka ʻōpio.
API a me ka hoʻomākaukau ʻana i nā mea maka: Hoʻohana ʻia ʻo NAD + i nā injections no ka mālama ʻana i ka lāʻau lapaʻau / kaohi, me ka NAD IV intravenous therapy i hoʻokō ʻia ma United States, Europe, Russia, South Africa, Mexico, South America, Southeast Asia a me nā ʻāina ʻē aʻe.ʻO nā huahana i hoʻomākaukau ponoʻī ʻia e ka Pharmacy, e like me nā lāʻau lapaʻau ʻAmelika, hiki ke kūʻai aku i nā mea maka no ka hāʻawi ʻana iā lākou iho, e like me ka hoʻomākaukau ʻana o ka halemai Kina, mālama ʻo ia i ka maikaʻi o nā mea maka, a hoʻomākaukau i ka hoʻomākaukau ʻana i nā lāʻau lapaʻau.
