Huli Huli Huli |Hōʻike ka haʻawina ʻo Tsinghua University hiki iā NMN ke mālama i ka mumū

ʻO ka hoʻoulu ʻana o ka macrophage he mea pathogenic e alakaʻi ai i ka mumū mau i loko o ke kino, akā ʻo ka hoʻomau ʻana o ka macrophage activation hiki ke alakaʻi i ka ʻeha mau a me nā maʻi e like me ke kū ʻana o ka insulin a me nā maʻi koʻikoʻi e like me ke atherosclerosis.ʻO ka PGE 2, ka mea e hoʻopili i ka pane inflammatory, ua synthesized mai ka arachidonic acid e cyclooxygenases (COX-1 a me COX-2).ʻO COX-1 a me COX-2 nā pahuhopu nui o ka anti-inflammatory a hiki ke kāohi ʻia e nā lāʻau anti-inflammatory non-steroidal (NSAIDs).

ʻO ka hoʻohana ʻana i nā NSAID hiki ke hoʻoulu i nā hopena maikaʻi ʻole, e like me ke kahe ʻana o ka ʻōpū.No laila, he mea koʻikoʻi ka loaʻa ʻana o kahi mea kūlohelohe palekana e mālama ai i ka mumū.

I kēia mau lā, ua mālama kahi hui noiʻi mai ke Kulanui ʻo Tsinghua i nā macrophages iole me NMN, a ua hōʻoia ʻia ma o nā hoʻokolohua hiki i ka NMN ke hōʻemi i ka hōʻiliʻili ʻana o nā protein e pili ana i ka mumū a me nā huahana metabolic, a ke kāohi i ka pane inflammatory o macrophages.Nā palena i loko o ka Molecular Biosciences.

Hoʻololi ka ʻā i nā pae o nā huahana metabolic i loko o nā macrophages
ʻO ka mea mua, ua hoʻāla ka hui noiʻi i nā macrophages e hana i ka mumū ma o ka lipopolysaccharide (LPS), a laila nānā i ka ʻike o nā huahana e pili ana i nā macrophages i ka wā o ka mumū.Ua hoʻonui ʻia nā pae o 99 metabolites a ua hoʻemi ʻia nā metabolites 105 ma waena o nā molekala 458 i ʻike ʻia ma mua a ma hope o ka hoʻoulu ʻana i ka inflammatory, a ua hoʻemi pū ʻia nā pae NAD+ e pili ana i ka mumū.

(KULA 1)

Hoʻonui ʻo NMN i nā pae NAD a hōʻemi i ka mumū macrophage
A laila mālama ka hui noiʻi i nā macrophage me LPS, kahi e hoʻoulu ai i kahi mokuʻāina inflammatory, IL-6 a me IL-1β, nā cytokine pro-inflammatory e hana i nā hōʻailona o ka mumū.Ma hope o ka hoʻomaʻamaʻa ʻana o ka NMN i ka maʻi macrophage i hoʻokomo ʻia e LPS, ua ʻike ʻia ua hoʻonui ʻia ka pae intracellular NAD a ua hoʻemi ʻia ka hōʻike mRNA o IL-6 a me IL-1β.Ua hōʻike ʻia nā hoʻokolohua ua hoʻonui ʻo NMN i ka pae o NAD a me ka hoʻoulu ʻana o ka macrophage LPS-induced.

( Kiʻi 2 )

( Kiʻi 3 )

Hoʻemi ʻo NMN i nā pae protein pili i ka mumū
ʻO ka mālama ʻana i ka NMN, ua ʻike ʻia ua hoʻemi ʻia nā protein e pili ana i ka mumū e like me RELL1, PTGS2, FGA, FGB a me igkv12-44 i loko o nā cell, i hōʻike ʻia ua hōʻemi ʻo NMN i ka hōʻike ʻana o nā protein pili i ka mumū.

( Kiʻi 4 )

Hoʻemi ʻo NMN i ka hōʻike ʻana o nā protein target NSAIDS
Ua ʻike ka hoʻokolohua hope loa ua hoʻemi ʻo NMN i ke kiʻekiʻe o ka PGE2 ma LPS-activated RAW264.7 cell ma o ka hoʻohaʻahaʻa ʻana i ka pae hōʻike o COX-2, ma laila e hoʻemi ai i ka hōʻike ʻana o COX2 a me ka pale ʻana i ka hoʻomohala ʻana o ka LPS.

( Kiʻi 6 )

ʻO ka hopena, hiki i ka supplementation o NMN ke mālama pono i ka mumū mau i nā ʻiole, a ʻo ka mālama ʻana i ka mumū i loko o ke kanaka pono e hōʻoia ʻia e nā hoʻokolohua lapaʻau kūpono.Malia paha e lilo ka NMN i mea pani no NSAIDS i ka wā e hiki mai ana.

nā kuhikuhi:
1.Liu J, Zong Z, Zhang W, Chen Y, Wang X, Shen J, Yang C, Liu X, Deng H. ʻO Nicotinamide Mononucleotide Hoʻopau i ka LPS-Induced Inflammation and Oxidative Stress ma o ka ho'ēmiʻana i ka COX-2 Expression i Macrophages.Mua Mol Biosci.2021 Iulai 6.