ʻO Clenbuterol, he β2-adrenergic agonist (β2-adrenergic agonist), e like me ka ephedrine (Ephedrine), hoʻohana pinepine ʻia e mālama i ka maʻi obstructive pulmonary maʻi (COPD), ua hoʻohana ʻia ʻo ia ma ke ʻano he bronchodilator e hoʻomaha i nā exacerbations o ka hānō.I ka 1980s mua, ua ʻike ʻole ʻia ka hui ʻAmelika ʻo Cyanamid he hopena maikaʻi ia o ka hoʻoulu ʻana i ka ulu, hoʻomaikaʻi i ka nui o ka ʻiʻo lean a me ka hoʻemi ʻana i ka momona, no laila ua hoʻohana ʻia ʻo clenbuterol i ka mahiʻai holoholona.Eia naʻe, ma muli o kona mau hopena ʻaoʻao, ua pāpā ka European Community i ka hoʻohana ʻana i ka clenbuterol ma ke ʻano he meaʻai meaʻai mai Ianuali 1, 1988. Ua pāpā ʻia e ka FDA ma 1991. I ka makahiki 1997, ua pāpā loa ke Kuhina o ka Mahiai o ka People's Republic of China. ka hoʻohana ʻana i nā hormones beta-adrenergic i ka hānai a me ka hana holoholona holoholona, a ʻo Clenbuterol hydrochloride ka mea mua.
Eia naʻe, ua hōʻike ʻia ka racemic Clenbuterol e hōʻemi i ka pilikia o ka maʻi o Parkinson.No ka hōʻoia i ka mea (a i ʻole nā mea ʻelua) e hoʻopuka i kēia hopena, pono ke aʻo ʻia ka Clenbuterol enantiomer maʻemaʻe.
I loko o kahi ʻatikala i hala iho nei, ʻo ka hui noiʻi o Elisabeth Egholm Jacobsen o ke Keʻena Kemika, Ke Kulanui o ʻEpekema a me ʻenehana ʻo Norwegian, me ka hui pū ʻana me Dr. Zhu Wei o Shangke Bio, i hoʻopaʻa i ka synthesis o ketoreductase KRED a me ka cofactor nicotinamide adenine dinucleoside phosphate (NADPH). ).(R)-1-(4-Amino-3,5-dichlorophenyl)-2-bromoethan-1-ol, ee > 93%;a me (S)-N-(2 i hoʻohui ʻia e ka ʻōnaehana like ,6-Dichloro-4-(1-hydroxyethyl)phenyl)acetamide, ee >98%.ʻO nā mea ʻelua ma luna nei he mau precursors o clenbuterol isomers.ʻO ka ketoreductase ES-KRED-228 i hoʻohana ʻia i kēia haʻawina mai Shangke Biopharmaceutical (Shanghai) Co., Ltd. ʻO ka hopena noiʻi "Chemoenzymatic Synthesis of Synthons as Precursors for Enantiopure Clenbuterol and Other -2-Agonists" i paʻi ʻia ma "Catalysts" ma Nowemapa 4, 2018.
Ka manawa hoʻouna: ʻAukake-26-2022