ʻO ka Hypopigmentation kahi maʻi ʻili, hōʻike nui ʻia e ka hoʻemi ʻana o ka melanin.ʻO nā hōʻailona maʻamau ka vitiligo, albinism a me ka hypopigmentation ma hope o ka mumū o ka ʻili.I kēia manawa, ʻo ka lāʻau lapaʻau nui no ka hypopigmentation ʻo ia ka lāʻau lapaʻau waha, akā ʻo ka lāʻau lapaʻau e hoʻoulu i ka ʻili atrophy, ʻeha ʻeha a me nā hopena ʻino ʻē aʻe.No laila, pono e hoʻomohala i kahi mea kūlohelohe me ka ʻole o nā hopena ʻaoʻao e mālama i ka hypopigmentation.
I kēia mau lā, ua hoʻopuka ʻo Scientific Reports i kahi ʻatikala i kapa ʻia "A systematic exploration reveals the potential of spermidine for hypopigmentation treatment | through the stabilization of melanogenesis-associated proteins".Hōʻike nā hopena i hiki ke mālama ʻia ka spermidine ma ka hoʻopaʻa ʻana i nā protein pili i ka melanogenesis.hypopigmentation.
一、 Hoʻonui ka hana ʻana o ka melanin i ka spermidine
I mea e aʻo ai i ka hopena o ka spermidine ma ka hana melanin, ua mālama ka hui noiʻi i ka melanin i loko o nā pūnaewele MNT-1 me nā ʻano ʻokoʻa o ka spermidine.Ma o ka helu helu ʻana, ua ʻike ʻia ua hoʻonui ʻia ka hana melanin i ka mālama ʻana i ka spermidine.
二、 Hiki i ka Spermidine ke hoʻoponopono i ka ʻōnaehana degradation protein e pili ana i ka melanogenesis
I mea e hōʻoia ai e hiki i ka spermidine ke hoʻoponopono i nā genes e pili ana i ka hoʻohaʻahaʻa ʻana i ka protein, ua ʻike ka hui noiʻi he 181 genes i hoʻoponopono ʻia a me 82 genes i hoʻoponopono ʻia e ka ʻōnaehana ʻike ʻana i nā cell i mālama ʻia i ka spermidine, me ka ʻole o nā genes pili i ka melanogenesis.No ka hōʻoia hou ʻana, ua kālailai ka hui noiʻi i ka hopena o ka spermidine i ka pae hōʻike o ka ʻohana gene tyrosinase TYR, TRP-1 a me TRP-2, ʻo ia nā genes e hoʻoponopono pono ana i ka hana melanin.Ua hōʻoia ka pae hōʻike mRNA ʻaʻole i hoʻololi ka spermidine i ka hōʻike o nā genes pili melanogenesis.Eia naʻe, hoʻololi ʻia ka hana o kekahi mau genes e ka spermidine a pili i ka hoʻohaʻahaʻa ʻana i ka protein.ʻO kekahi mau genes i hoʻololi ʻia e pili ana i ka ubiquity, kahi ʻōnaehana hoʻohaʻahaʻa protein e pili ana i ka melanogenesis.
三．Spermidine hoʻoponopono i ka paʻa o nā protein a hoʻoikaika i ka hana melanin.
Hoʻoponopono ʻia ka hana ʻana o ka melanin e ke kaulike o ka synthesis a me ka hoʻohaʻahaʻa ʻana i nā protein pili melanin.Mālama ʻo Spermidine i nā genes TYR, TRP-1 a me TRP-2.Ma o ka hana a nā genes transporter SLC3A2, SLC7A1, SLC18B1 a me SLC22A18, hiki iā ia ke hoʻonui i ke kiʻekiʻe o nā polyamines i loko o nā pūnaewele, pēlā e hoʻonui ai i ka paʻa o nā protein e pili ana i ka hana melanin e hoʻoikaika i ka hana melanin i vivo.
I ka hopena, ua hōʻike kēia haʻawina he kuleana ko ka spermidine hui maoli i ka mālama ʻana i ka hypopigmentation, a loaʻa kekahi waiwai noi i ke kahua o nā mea hoʻonaninani a me nā huahana olakino i ka wā e hiki mai ana.
Kuhikuhi:
[1].Brito, S., Heo, H., Cha, B. et al.Hōʻike ka ʻimi ʻōnaehana i ka hiki o ka spermidine no ka mālama ʻana i ka hypopigmentation ma o ka hoʻopaʻa ʻana o nā protein pili i ka melanogenesis. Sci Rep 12, 14478 (2022).https://doi.org/10.1038/s41598-022-18629-3.
Ka manawa hoʻouna: Sep-28-2022