He maʻi ʻili ka hypopigmentation, i hōʻike nui ʻia e ka hoʻemi ʻana o ka melanin. ʻO nā hōʻailona maʻamau e pili ana i ka vitiligo, albinism a me ka hypopigmentation ma hope o ka mumū ʻana o ka ʻili. I kēia manawa, ʻo ka lāʻau lapaʻau waha ka lāʻau lapaʻau nui no ka hypopigmentation, akā ʻo ka lāʻau lapaʻau waha e hoʻoulu ai i ka atrophy o ka ʻili, ka ʻeha ʻōpū a me nā hopena ʻino ʻē aʻe. No laila, pono e hoʻomohala i kahi mea kūlohelohe me ka ʻole o nā hopena ʻaoʻao e mālama ai i ka hypopigmentation.
I kēia mau lā iho nei, ua paʻi ʻo Scientific Reports i kahi ʻatikala i kapa ʻia ʻo "A systematic exploration reveals the potential of spermidine for hypopigmentation treatment | through the stabilization of melanogenesis-associated proteins". Hōʻike nā hopena hiki ke mālama ʻia ka spermidine ma o ka hoʻopaʻa ʻana i nā protein melanogenesis-associated hypopigmentation.
Hoʻonui ka mālama ʻana o Spermidine i ka hana ʻana o ka melanin
I mea e aʻo ai i ka hopena o ka spermidine i ka hana ʻana o ka melanin, ua mālama ka hui noiʻi i ka melanin i loko o nā pūnaewele MNT-1 me nā ʻano like ʻole o ka spermidine. Ma o ka nānā ʻana i ka nui, ua ʻike ʻia ua hoʻonui ka mālama ʻana o ka spermidine i ka hana ʻana o ka melanin.
Eia kekahi, hiki i ka Spermidine ke hoʻoponopono i ka ʻōnaehana hōʻino protein e pili ana i ka melanogenesis
I mea e hōʻoia ai e hiki i ka spermidine ke hoʻoponopono i nā genes e pili ana i ka hoʻohaʻahaʻa ʻana o ka protein, ua ʻike ka hui noiʻi he 181 mau genes i hoʻohaʻahaʻa ʻia a he 82 mau genes i hoʻonui ʻia e ka ʻike ʻana i nā cell i mālama ʻia me ka spermidine, koe wale nō nā genes e pili ana i ka melanogenesis. No ka hōʻoia hou aku, ua kālailai ka hui noiʻi i ka hopena o ka spermidine ma ka pae hōʻike o ka ʻohana gene tyrosinase TYR, TRP-1 a me TRP-2, ʻo ia nā genes e hoʻoponopono pono ana i ka hana melanin. Ua hōʻoia ka pae hōʻike mRNA ʻaʻole i hoʻololi ka spermidine i ka hōʻike ʻana o nā genes e pili ana i ka melanogenesis. Eia nō naʻe, ua hoʻololi ʻia ka hana o kekahi mau genes e ka spermidine a pili i ka hoʻohaʻahaʻa ʻana o ka protein. Pili kekahi mau genes i hoʻololi ʻia i ka ubiquity, ʻo ia kahi ʻōnaehana hoʻohaʻahaʻa protein e pili ana i ka melanogenesis.
Hoʻoponopono ʻo Spermidine i ke kūpaʻa o nā protein a paipai i ka hana ʻana o ka melanin.
Hoʻoponopono ʻia ka hana ʻana o ka melanin e ke kaulike o ka synthesis a me ka degradation o nā protein e pili ana i ka melanin. Hoʻōla ʻo Spermidine i nā genes TYR, TRP-1 a me TRP-2. Ma o ka hana a nā genes transporter SLC3A2, SLC7A1, SLC18B1 a me SLC22A18, hiki iā ia ke hoʻonui i ka pae o nā polyamines i loko o nā cell, no laila e hoʻonui ana i ke kūpaʻa o nā protein e pili ana i ka hana ʻana o ka melanin e hoʻolaha i ka hana ʻana o ka melanin in vivo.
I ka hopena, ua hōʻike kēia haʻawina he kuleana ko ka hui kūlohelohe spermidine i ka mālama ʻana i ka hypopigmentation, a he waiwai hoʻohana koʻikoʻi kona ma ke kahua o nā mea hoʻonani a me nā huahana olakino i ka wā e hiki mai ana.
Kuhikuhi:
[1]. Brito, S., Heo, H., Cha, B. et al. Hōʻike kahi noiʻi ʻōnaehana i ka hiki o ka spermidine no ka mālama ʻana i ka hypopigmentation ma o ka hoʻopaʻa ʻana o nā protein e pili ana i ka melanogenesis.Sci Rep 12, 14478 (2022). https://doi.org/10.1038/s41598-022-18629-3.
Ka manawa hoʻouna: Sep-28-2022
