Molecular Metabolism: Ka hopena therapeutic o NMN supplementation ma polycystic ovary syndrome

I nā makahiki i hala iho nei, me ka piʻi ʻana o ke ola kino ʻole a me ka piʻi ʻana o ke kaumaha o ka nohona o nā wahine, ua ʻike ʻia ka nui o ka maʻi o ka polycystic ovary syndrome (PCOS).Ua hōʻike ʻia nā haʻawina haole ʻo ka nui o ka maʻi o ka polycystic ovary syndrome (PCOS) i nā wahine o ka wā hānau keiki he 6% -15%, ʻoiai ma Kina, ʻoi aku ka nui o ka 6% -10%.

ʻO ka maʻi polycystic ovary kahi maʻi i loaʻa pinepine i nā wahine hānau keiki ma muli o nā maʻi endocrine.Hōʻike nui ʻia ia i ka glucose abnormal a me ka lipid metabolism a me ka hana hānau hānau.ʻO nā pae hoʻohālikelike o ka maʻi maʻi he maʻi o ka hormone level (high androgen), dilute Ovulation disorders a me nā loli polycystic ovarian, a ʻo ka hapa nui o nā wahine me ka PC COS he mau hiʻohiʻona ʻino, e like me ke kūpaʻa insulin, ka momona, a me ka steatosis hepatic.

I kēia manawa, liʻiliʻi nā lāʻau lapaʻau no ka mālama ʻana i ka PCOS.ʻO ke ala maʻamau ʻo ka hoʻomaikaʻi ʻana i ka PCOS ma ka huli ʻana a me ke kāohi ʻana i ka nui o ka androgen me nā lāʻau anti-androgen.Eia nō naʻe, aia kekahi mau hōʻike e loaʻa i nā lāʻau anti-androgen ka ʻona o ka ate, no laila ua kaupalena ʻia kā lākou hoʻohana.No laila, he mea nui loa ka ʻimi ʻana i kahi mea kūlohelohe me ka ʻole o nā hopena ʻaoʻao e pani ai i nā lāʻau lapaʻau o kēia manawa.

ʻO ka noiʻi hou ʻana e ke Kulanui o New South Wales ma Australia ua ʻike ʻo ka polycystic ovary syndrome e pili ana i ka hemahema NAD +, a ua paʻi ʻia nā hopena noiʻi ma ka nūpepa ʻepekema "Molecular Metabolism".

Hoʻokomo mua ka hui noiʻi i ka dihydrotestosterone (DHT) subcutaneously i nā ʻiole wahine ma mua a ma hope o ka wā ʻōpio e hoʻokumu i kahi kumu ʻiole PC COS, a laila ma hope o 8 mau pule o ka mālama ʻana i ka NMN, hoʻokē ʻai i ka insulin a me ka HOMA insulin resistance detection, glucose tolerance test, fat Ma hope o nā hoʻokolohua like e like me ka histomorphometry, hōʻike nā hopena helu:

1. Hoʻihoʻi ʻo N MN i ka N AD + pae ma ka ʻiʻo o nā ʻiole P COS
Ua ʻike ʻia ua hoʻemi nui ʻia ka pae NAD+ i loko o ka ʻiʻo o nā ʻiole PCOS, a ua hoʻihoʻi ʻia ka pae NAD i ka ʻiʻo o nā ʻiole PCOS e ka hānai ʻana iā NMN.

2. Hoʻomaikaʻi ʻo NMN i ka pale ʻana o ka insulin a me ka momona i nā ʻiole PCOS
ʻOi aku ka nui o ka insulin i hoʻokomo ʻia e DHT ma mua o ka pālua ʻana i nā ʻiole PCOS hoʻokēʻai, e hōʻike ana paha i ka pale ʻana o ka insulin.Ma ka hānaiʻana iā NMN, uaʻikeʻia ua hoʻihoʻi houʻia ka pae insulin hoʻokēʻai i ka pae kokoke i nāʻiole maʻamau.Eia kekahi, ua hoʻonui ʻia ke kaumaha o ke kino o nā ʻiole PCOS e 20%, a ua piʻi nui ka momona.

3. Ho'iho'i 'o NMN i ka waiho 'ana o ka lipid hepatic ma'amau i nā 'iole PCOS
ʻO kekahi o nā hiʻohiʻona o ka maʻi polycystic ovary ʻo ia ka lipid deposition i loko o ke ake a me ka induction o ka momona momona.Ma hope o ka lawe ʻana i ka NMN, ua aneane hoʻopau ʻia ka waiho ʻana o ka lipid ate ma nā ʻiole PCOS, a ua hoʻi nā triglycerides i loko o ke ake i ke kiʻekiʻe o nā ʻiole maʻamau.

ʻO ka hopena, ua hoʻemi nui ʻia ke kiʻekiʻe o NAD+ i loko o ka ʻiʻo o PCOS, a ua hoʻohaʻahaʻa ʻia ke kūlana o ka PCOS ma o ka hoʻohui ʻana i ka NMN, ka mea mua o NAD+, ʻo ia paha kahi hoʻolālā lapaʻau kūpono no ka mālama ʻana i ka PCOS.

nā kuhikuhi:
[1].Aflatounian A, Paris VR, Richani D, Edwards MC, Cochran BJ, Ledger WL, Gilchrist RB, Bertoldo MJ, Wu LE, Walters KA.ʻO ka hoʻohaʻahaʻa ʻana i ka ʻiʻo NAD + i kahi hiʻohiʻona kiʻi hyperandrogenism PCOS: hiki ke hana i ka metabolic dysregulation.Mol Metab.2022 Sep 9;65:101583.doi: 10.1016/j.molmet.2022.101583.Epub ma mua o ka paʻi.PMID: 36096453.