ʻO ka Metabolism Molecular: Ka hopena therapeutic o ka hoʻopihapiha NMN ma ka maʻi polycystic ovary

I nā makahiki i hala iho nei, me ka piʻi ʻana o nā nohona maikaʻi ʻole a me ka piʻi ʻana o ke kaomi kaiāulu o nā wahine, ua lilo ka nui o ka maʻi polycystic ovary syndrome (PCOS) i mea maopopo loa. Ua hōʻike ʻia nā noiʻi haole he kiʻekiʻe ka nui o ka maʻi polycystic ovary syndrome (PCOS) i nā wahine o ka wā hānau keiki he 6% -15%, ʻoiai ma Kina, ua kiʻekiʻe ka hapa i ka 6% -10%.

ʻO ka maʻi polycystic ovary kahi maʻi e loaʻa pinepine i nā wahine o ka wā hānau keiki ma muli o nā maʻi endocrine. Hōʻike nui ʻia ia i ka glucose maʻamau a me ka metabolism lipid a me ka hana ʻole o ka hānau ʻana. ʻO nā pae hōʻoia lapaʻau he maʻi pae hormone (androgen kiʻekiʻe), nā maʻi Ovulation dilute a me nā loli polycystic ovarian, a ʻo ka hapa nui o nā wahine me PC COS he mau hiʻohiʻona metabolic maikaʻi ʻole, e like me ke kūʻē ʻana o ka insulin, ka momona, a me ka steatosis hepatic.

I kēia manawa, he kakaikahi nā lāʻau lapaʻau no ka mālama ʻana i ka PCOS. ʻO ke ʻano maʻamau ka hoʻomaikaʻi ʻana i ka PCOS ma o ka hoʻopaʻa ʻana a me ka pale ʻana i ka nui o ka androgen me nā lāʻau anti-androgen. Eia nō naʻe, aia kekahi hōʻike e loaʻa i nā lāʻau anti-androgen ka ʻona ikaika o ke akepaʻa, no laila ua kaupalena ʻia kā lākou hoʻohana. No laila, he mea nui loa ka ʻimi ʻana i kahi mea kūlohelohe me ka ʻole o nā hopena ʻaoʻao e pani i nā lāʻau lapaʻau o kēia manawa.

Ua ʻike ʻia kahi noiʻi hou a ke Kulanui o New South Wales ma Australia e pili ana ka maʻi polycystic ovary i ka hemahema o NAD+, a ua paʻi ʻia nā hopena noiʻi ma ka puke pai ʻepekema "Molecular Metabolism".

Ua hoʻokomo mua ka hui noiʻi i ka dihydrotestosterone (DHT) ma lalo o ka ʻili i loko o nā ʻiole wahine ma mua a ma hope o ka wā ʻōpiopio e hoʻokumu i kahi kumu hoʻohālike ʻiole PC COS, a laila ma hope o 8 mau pule o ka mālama ʻana iā NMN, ka insulin hoʻokē ʻai a me ka ʻike ʻana i ke kūpaʻa insulin HOMA, ka hoʻāʻo hoʻomanawanui glucose, ka momona Ma hope o nā hoʻokolohua e like me ka histomorphometry, hōʻike nā hopena helu:

1. Hoʻihoʻi ʻo N MN i ka pae N AD + i loko o ka ʻiʻo o nā ʻiole P COS
ua ʻike ʻia ua emi nui ka pae NAD+ i loko o ka ʻiʻo o nā ʻiole PCOS, a ua hoʻihoʻi ʻia ka pae NAD i loko o ka ʻiʻo o nā ʻiole PCOS e ka hānai ʻana iā NMN.

2. Hoʻomaikaʻi ka NMN i ke kū'ē ʻana o ka insulin a me ka momona i nā ʻiole PCOS
Ua ʻoi aku ka pālua o nā pae insulin i hoʻokomo ʻia e DHT i nā ʻiole PCOS hoʻokē ʻai, e hōʻike ana paha i ke kūʻē ʻana o ka insulin. Ma ka hānai ʻana iā NMN, ua ʻike ʻia ua hoʻihoʻi ʻia ka pae insulin hoʻokē ʻai i ka pae kokoke i ko nā ʻiole maʻamau. Eia kekahi, ua piʻi ke kaumaha o ke kino o nā ʻiole PCOS ma 20%, a ua piʻi nui ka momona.

3. Hoʻihoʻi ʻo NMN i ka waiho ʻana o ka lipid hepatic maʻamau i nā ʻiole PCOS
ʻO kekahi o nā ʻano o ka polycystic ovary syndrome ʻo ia ka waiho ʻana o ka lipid i loko o ke akepaʻa a me ka hoʻoulu ʻana o ke akepaʻa momona. Ma hope o ka lawe ʻana i ka NMN, ua aneane pau ka waiho ʻana o ka lipid ate maʻamau ʻole i loko o nā ʻiole PCOS, a ua hoʻi hou nā triglycerides i loko o ke akepaʻa i ka pae o nā ʻiole maʻamau.

ʻO ka hopena, ua hoʻemi nui ʻia ka pae o NAD+ i loko o ka ʻiʻo o PCOS, a ua hoʻomaha ʻia ke kūlana o PCOS ma ka hoʻohui ʻana iā NMN, ka mea mua o NAD+, kahi paha he hoʻolālā therapeutic kūpono no ka mālama ʻana i ka PCOS.

nā kuhikuhi:
[1]. ʻO Aflatounian A, Paris VR, Richani D, Edwards MC, Cochran BJ, Ledger WL, Gilchrist RB, Bertoldo MJ, Wu LE, Walters KA. Ke emi ʻana o ka ʻiʻo NAD+ i loko o kahi kumu hoʻohālike ʻiole PCOS hyperandrogenism: He kuleana paha i ka metabolic dysregulation. Mol Metab. 2022 Sep 9;65:101583. doi: 10.1016/j.molmet.2022.101583. Epub ma mua o ka paʻi ʻana. PMID: 36096453.