ʻO ka fibrosis ʻōpū i hoʻoulu ʻia e ka radiation kahi pilikia maʻamau o ka poʻe i ola lōʻihi ma hope o ka radiotherapy ʻōpū a me ka pelvic. I kēia manawa, ʻaʻohe ala i loaʻa i ke kauka e mālama ai i ka fibrosis ʻōpū i hoʻoulu ʻia e ka radiation. Ua hōʻike nā haʻawina he hiki i ka nicotinamide mononucleotide (NMN) ke hoʻoponopono i ka flora ʻōpū. ʻO ka flora ʻōpū kahi microorganism maʻamau i loko o nā ʻōpū kanaka, hiki ke hana i nā ʻano meaʻai like ʻole e pono ai no ka ulu ʻana a me ka hoʻomohala ʻana o ke kanaka. Ke kaulike ʻole ka flora ʻōpū, e hoʻoulu ia i nā ʻano maʻi like ʻole.
I kēia mau lā iho nei, ua paʻi ʻo China Academy of Medical Sciences a me Peking Union Medical College i nā hopena noiʻi ma ka puke pai International Journal of Radiation Biology, kahi i hōʻike ai e hiki i ka NMN ke hōʻemi i ka fibrosis intestinal i hoʻokumu ʻia e ka radiation ma o ka hoʻoponopono ʻana i ka flora intestinal.
I ka wā mua, ua māhele ka hui noiʻi i nā ʻiole i loko o ka hui kaohi, ka hui NMN, ka hui IR a me ka hui NMNIR, a hāʻawi i ka 15 Gy irradiation ʻōpū i ka hui IR a me ka hui NMNIR. I kēia manawa, ua hāʻawi ʻia ka mea hoʻohui NMN i ka hui NMN a me ka hui NMNIR ma kahi mahele lā o 300mg/kg. Ma hope o ka lawe ʻana no kekahi manawa, ma ka ʻike ʻana i nā ʻōpala ʻiole, ka microflora ʻōpū a me nā māka ʻiʻo colon, ua hōʻike nā hopena hoʻohālikelike:
1. Hiki i ka NMN ke hoʻoponopono i ka haku mele a me ka hana o nā flora ʻōpū i hoʻopilikia ʻia e ka radiation.
Ma ka hoʻohālikelike ʻana i ka ʻike ʻana o nā flora ʻōpū ma waena o ka hui IR a me ka hui NMNIR, ua ʻike ʻia ua hoʻonui nā ʻiole hui IR i ka nui o nā flora ʻōpū ʻino, e like me Lactobacillus du, Bacillus faecalis, a pēlā aku. ʻO ka mea kupanaha, ua hoʻololi nā ʻiole hui NMNIR i ke ʻano like ʻole o nā flora ʻōpū a hoʻonui i ka nui o nā flora ʻōpū maikaʻi, e like me ka bacteria AKK, ma ka hoʻohui ʻana iā NMN. Hōʻike nā hoʻokolohua hiki iā NMN ke hoʻoponopono i ka haku mele a me ka hana o nā flora ʻōpū i kū ʻole i ke kaulike ma muli o ka radiation.
2. Hoʻomaha ka NMN i ka fibrosis ʻōpū i hoʻokumu ʻia e ka radiation
Ua piʻi nui ka pae o ka aSMA (Fibrosis Marker) i loko o nā ʻiole i hōʻike ʻia i ka radiation. Ma hope o ka hoʻohui ʻana o NMN, ʻaʻole wale ka pae o ka māka aSMA i emi nui, akā ua emi nui ka mea hoʻonāukiuki TGF-b nāna i hoʻolaha i ka fibrosis ʻōpū, e hōʻike ana hiki i ka hoʻohui ʻana o NMN ke hōʻemi i ka fibrosis ʻōpū i hoʻokumu ʻia e ka radiation.
(Kiʻi 1. Hoʻemi ka lāʻau NMN i ka fibrosis ʻōpū i hoʻokumu ʻia e ka radiation)
Ma lalo o ke kua o ka laha ʻana o nā huahana uila, ʻoi aku ka hopena o ka radiation i ka hana a me ke ola o kānaka, ʻoi aku hoʻi i nā flora ʻōpū no ka manawa lōʻihi. He hopena pale ikaika ko NMN i ke olakino ʻōpū. ʻAʻole ʻike wale ʻia kēia hopena e kahi mea hoʻokahi a i ʻole kekahi ala, akā ma o ka hoʻoponopono ʻana i ke ʻano hoʻolaha o nā flora e hoʻolaha i ke kūpaʻa o ka hana ʻōpū mai nā kihi a me nā kuhikuhi like ʻole, kahi e hāʻawi pū ai i kahi kuhikuhi koʻikoʻi no nā pono like ʻole o NMN.
Nā Kuhikuhi:
Xiaotong Zhao, Kaihua Ji, Manman Zhang, Hao Huang, Feng Wang, Yang Liu & Qiang Liu (2022): NMN alleviates radiation-induced intestinal fibrosis by modulating gut microbiota, International Journal of Radiation Biology, DOI: 10.1080/09553002.2023
Ka manawa hoʻouna: Dec-08-2022