Hoʻopau ka NMN i ka fibrosis intestinal i hoʻoulu ʻia e ka radiation ma o ka hoʻololi ʻana i ka microbiota gut

ʻO ka fibrosis intestinal i hoʻoulu ʻia e ka radiation he hoʻopiʻi maʻamau o nā mea ola lōʻihi ma hope o ka radiotherapy abdominal a pelvic.I kēia manawa, ʻaʻohe ala lapaʻau e mālama ai i ka fibrosis intestinal i hoʻoiho ʻia e ka radiation.Ua hōʻike nā haʻawina i ka nicotinamide mononucleotide (NMN) hiki ke hoʻoponopono i ka flora intestinal.ʻO ka flora intestinal he microorganism maʻamau i loko o ka ʻōpū o ke kanaka, hiki iā ia ke synthesize i nā ʻano meaʻai e pono ai no ka ulu a me ka ulu ʻana o ke kanaka.I ka pau ʻana o ke kaulike o ka ʻōpū, e hoʻoulu ʻia nā maʻi like ʻole.
I kēia mau lā, ua paʻi ʻo China Academy of Medical Sciences a me Peking Union Medical College i nā hopena noiʻi ma ka puke pai International Journal of Radiation Biology, i hōʻike ʻia e hiki i ka NMN ke hōʻemi i ka fibrosis ʻōpū i hoʻokumu ʻia e ka radiation ma o ka hoʻoponopono ʻana i ka flora intestinal.
I ka wā mua, ua hoʻokaʻawale ka hui noiʻi i nā ʻiole i ka pūʻulu mana, NMN pūʻulu, IR pūʻulu a me NMNIR pūʻulu, a hāʻawi iā 15 Gy abdominal irradiation i ka hui IR a me ka hui NMNIR.I kēia manawa, hāʻawi ʻia ka waihona NMN i ka hui NMN a me ka hui NMNIR i kēlā me kēia lā o 300mg/kg.Ma hope o ka lawe ʻana iā ia no kekahi manawa, ma ka ʻike ʻana i nā feces ʻiole, ka microflora intestinal a me nā hōʻailona kiko kiko, ua hōʻike nā hopena hoʻohālikelike:

1. Hiki i ka NMN ke hoʻoponopono i ka haku mele ʻana a me ka hana o nā pua ʻōpū i hoʻopilikia ʻia e ka radiation.
Ma ka hoʻohālikelike ʻana i ka ʻike ʻana o ka ʻōpū ʻōpū ma waena o ka hui IR a me ka pūʻulu NMNIR, ua ʻike ʻia ua hoʻonui ʻia nā ʻiole hui IR i ka nui o nā flora intestinal ʻino, e like me Lactobacillus du, Bacillus faecalis, a pēlā aku. a hoʻonui i ka nui o nā mea kanu ʻono maikaʻi, e like me ka bacteria AKK, ma ka hoʻonui ʻana i ka NMN.Hōʻike nā hoʻokolohua hiki i ka NMN ke hoʻoponopono i ke ʻano a me ka hana o nā pua ʻōpū ʻaʻole kaulike ma muli o ka radiation.

2. Hoʻopau ka NMN i ka fibrosis ʻōpū ma muli o ka radiation
Ua piʻi nui ka pae o ka aSMA (Fibrosis Marker) i nā ʻiole i ʻike ʻia i ka radiation.Ma hope o ka hoʻonui ʻana i ka NMN, ʻaʻole wale ka pae o ka marker aSMA i emi nui, akā ʻo ka mea inflammatory TGF-b ka mea i hāpai i ka fibrosis intestinal ua emi nui, e hōʻike ana e hiki i ka supplementation NMN ke hōʻemi i ka fibrosis intestinal i hana ʻia e ka radiation.

(Figure 1. Hoʻemi ka lāʻau NMN i ka fibrosis intestinal i hana ʻia e ka radiation)

Ma lalo o ke kumu o ka laha ʻana o nā huahana uila, piʻi ka hopena o ka radiation i ka hana a me ke ola o nā kānaka, ʻoi aku hoʻi i ka flora intestinal no ka manawa lōʻihi.He hopena pale ikaika ko NMN i ke ola kino.ʻAʻole ʻike wale ʻia kēia hopena e ka mea hoʻokahi a i ʻole kekahi ala, akā ma ka hoʻoponopono ʻana i ka hoʻohelehele ʻana o ka flora e hoʻoikaika i ka paʻa o ka hana o ka ʻōpū mai nā kihi like ʻole a me nā kuhikuhi, e hāʻawi pū ana i kahi kuhikuhi nui no nā pono like ʻole o NMN.

Kuhikuhi:
Xiaotong Zhao, Kaihua Ji, Manman Zhang, Hao Huang, Feng Wang, Yang Liu & Qiang Liu (2022): NMN alleviates radiation-induced intestinal fibrosis by modulating gut microbiota, International Journal of Radiation Biology, DOI: 10.1080/09553002.2023