Ua komo ʻo Shangke Bio lāua ʻo Zhejiang Supor Pharmaceutical Co., Ltd. i ka 2020 Nanjing API CHINA API Exhibition a ua hana i kahi hōʻike hoʻonaʻauao kūikawā ma NMN

Ua hāʻawi ʻo Kauka Zhu i kahi haʻiʻōlelo mai ka hoʻomohala ʻana o NMN, a ua wehe mālie i ka mea pohihihi o ka lāʻau anti-aging NMN: Ua pōkole ʻia ʻo NMN ʻo β-nicotinamide mononucleotide, ʻo ia ka mea mua o NAD+; hōʻoia nā hopena hoʻokolohua pili i paʻi ʻia ma kahi moʻo o nā puke pai ʻepekema honua kiʻekiʻe, manaʻoʻiʻo ʻo ia e emi ana ka nui o NAD+ i loko o ke kino kanaka me ka makahiki, e alakaʻi ana i ka ʻelemakule mai ka makahiki 30, me nā wrinkles, ka hoʻomaha ʻana o nā ʻiʻo, ka hōʻiliʻili momona, a me ka hoʻonui ʻia o ka maʻi puʻuwai, ke koko kiʻekiʻe, ka hahau ʻana, ka maʻi diabetes, a me ka maʻi Alzheimer. Ua ʻike ʻia ke aʻo ʻana i ka wā e haʻahaʻa ai nā cell i NAD+, pane lākou ma ka hōʻike ʻana i ka nui o ka mea lawe SLC12A8, e ʻae ana i ka omo pono ʻana o NMN mai ke kahe koko, ʻoiai ua ʻike ʻia ka gene transporter SLC12A8 e hōʻike ʻia i loko o nā ʻiʻo he nui a me ka ʻōpū. Kiʻekiʻe loa ka nui o ka mea i loko o ke ala. I loko o ka ʻōpū, ua omo koke ʻia ʻo NMN mai ka ʻōpū liʻiliʻi i loko o 2-3 mau minuke a hoʻololi ʻia i NAD+ i loko o 10-30 mau minuke.

Ua hōʻoia ʻia ka hopena anti-kahiko o NMN a ua kākoʻo ʻia e ka hapa nui o nā hihia maoli. I kēia manawa, ua lilo ʻo Iapana i ʻāina i ʻae kū kānāwai iā NMN ma ke ʻano he meaʻai maka.

I Ianuali 2019, he 188 wale nō huahana a NMN ma ka pūnaewele holoʻokoʻa, a i ka hopena o ʻAukake 2020, ua ʻoi aku ka nui o nā huahana ma ka pūnaewele kūloko holoʻokoʻa ma mua o 2,962. Aia ka hoʻonui ʻia ʻana o nā huahana, ka nele o nā kūlana ʻoihana, a me ka nele o ka noʻonoʻo ʻana i ka palekana a me ka pono. Eia kekahi, nele ka nui o nā hōʻailona NMN i ka ʻenehana koʻikoʻi, a ua hui pū ʻia nā huahana.

ʻO ka mākeke huahana anti-kahiko honua (me ʻekolu mau ʻano o nā huahana mālama hoʻonaninani, nā huahana meaʻai a me nā huahana anti-kahiko lāʻau lapaʻau) ua waiwai ʻia ma US $ 250 biliona i ka makahiki 2016 a ua manaʻo ʻia e ulu ma kahi CAGR o 5.8% e hiki aku i US $ 331.41 biliona ma 2021. ʻO ʻAmelika ʻĀkau i kēia manawa ke alakaʻi i ka mākeke anti-kahiko honua, ukali ʻia e ʻEulopa a me Iapana, a ua manaʻo ʻia ʻo Asia Pacific ka ʻāina ulu wikiwiki loa ma ka honua i ka wā e hiki mai ana. I kēia manawa, ʻo nā mea hoʻolako mea maka honua o NMN e kau nui ʻia ma Kina, a ʻo nā kaʻina hana e komo pū ana me ka synthesis kemika, ka synthesis kemika-enzymatic a me ke ʻano enzymatic holoʻokoʻa. ʻO ka noiʻi lapaʻau kūpono ma nā hana pili o NMN ke kumu no ka ulu ʻana o ka mākeke e hiki mai ana, a ʻo ka mālama kānāwai a me ka localization nā kumu nui no ka hoʻomohala ʻana i ka mākeke e hiki mai ana. He kuleana koʻikoʻi ko Coenzyme i ke kaʻina hana o ka metabolism physiological kanaka, a ua hoʻohana nui ʻia kāna huahana i ka ʻoihana meaʻai a me nā huahana olakino. Eia kekahi, ʻo coenzyme ke kumu o nā biopharmaceuticals ʻōmaʻomaʻo.

ʻO Shangke Bio kahi ʻoihana e hoʻokō ana i ka hana ʻana o ka coenzyme NMN/NAD/NADH/NADP/NADPH a me nā huahana ʻē aʻe ma o ka ʻenehana catalysis enzyme holoʻokoʻa, a ua hala i ka palapala hōʻoia ʻōnaehana hoʻokele maikaʻi ISO9001, SELF GRAS (loiloi ka US FDA i ka helu palekana o nā mea hoʻohui meaʻai) Ua lanakila ka palapala hōʻoia palekana a me ka palapala hōʻoia "acute oral toxicity test" i kahi inoa maikaʻi i ka ʻoihana, a ua hoʻokuʻu ʻia aku nā huahana i ka honua.