Amine Dehydrogenase (AmDH)
ʻO ka wehewehe pōkole:
E pili ana iā Amine Dehydrogenase
ES-AmDH (Amine Dehydrogenase): he enzyme e hiki ke hoʻokahe i ka ammoniation o ka hui kalapona a hoʻemi ia i ka hui amino.He enzyme hilinaʻi coenzyme NADH, a hana ʻo NADH ma ke ʻano he hydrogen transmitter.He 4 mau ʻano huahana enzyme AmDH (Helu e like me ES-AmDH101～ES-AmDH104) i hoʻomohala ʻia e SyncoZymes, hiki ke hoʻohana ʻia i ka regioselective a i ʻole stereoselective reductive amination o nā aldehydes a me nā ketones.
ʻAno hoʻopā catalytic:
Mobile/Wechat/WhatsApp: +86-13681683526
E-Mail:lchen@syncozymes.com
★ High substrate specificity.
★ Ke koho kiral ikaika.
★ hoʻololi kiʻekiʻe.
★ Liʻiliʻi nā huahana.
★ Kūlana haʻahaʻa haʻahaʻa.
★ Pili kaiapuni.
➢ ʻO ka mea maʻamau, pono e hoʻokomo i ka ʻōnaehana hoʻololi i ka substrate, ka solution buffer, ka enzyme, ka coenzyme a me ka coenzyme regeneration system (e laʻa me ka glucose a me ka glucose dehydrogenase).
➢ Pono e hoʻohui hope ʻia ka AmDH i loko o ka ʻōnaehana pane, ma hope o ka hoʻololi ʻana o ka pH a me ka mahana i ke ʻano o ka hopena.
Ka Laʻana 1(Synthesis o nā amine chiral like me ka hoʻohaʻahaʻa ʻana o nā alkyl aryl ketones)(1):
E mālama i 2 mau makahiki ma lalo o -20 ℃.
Mai launa pū me nā kūlana koʻikoʻi e like me: ka wela kiʻekiʻe, ka pH kiʻekiʻe/haʻahaʻa a me ka mea hoʻoheheʻe organik kiʻekiʻe.
1. Kong W, Liu Y, Huang C, et al.ʻO Angewandte Chemie International Edition, 2022: e202202264.
