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ʻO ka D-Amino acid dehydrogenase (D-AADH)
E pili ana i ka D-Amino acid dehydrogenase
ʻO ES-D-AADH (D-Amino acid dehydrogenase): kahi enzyme e hiki ke hoʻemi i ka 2-keto acid i loko o ka D-amino acid e pili ana. Pono ka hopena i ka NADP(H) a me ka mea hāʻawi ammonia inorganic (e like me ka ammonia a i ʻole ka ammonium ion). Aia he 17 ʻano o nā D-amino acid dehydrogenases (Helu e like me ES-DAADH-101 ~ ES-DAADH-117) i hoʻomohala ʻia e SyncoZymes.
ʻAno hana catalytic:
Kelepona Paʻalima/Wechat/WhatsApp: +86-13681683526
Leka uila:lchen@syncozymes.com
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ʻEsterase a me Lipase (PLE a me CALB)
E pili ana iā Esterase & Lipase
ES-PLEs: He papa o nā hydrolases e hoʻoulu ai i ka hoʻokumu ʻana a me ka haki ʻana o nā pilina ester. Hiki iā lākou ke komo i nā ʻano hopena biochemical he nui, e like me ka esterification, transesterification a me ka hydrolysis. Hoʻohana nui ʻia lākou ma nā ʻano he nui e like me ka hana ʻana i ka meaʻai, ka ʻoihana kemika, ka biomedicine, ka lāʻau lapaʻau chiral a me ka mālama ʻana i ke kaiapuni.
Kelepona Paʻalima/Wechat/WhatsApp: +86-13681683526
Leka uila:lchen@syncozymes.com
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ʻEpoxide hydrolase (EH)
E pili ana i ka epoxide hydrolase
ʻO EH ka ether hydrolase e hoʻoulu ai i ka hydrolysis stereoselective o nā racemic epoxides e hana i ka 1, 2-diol a me nā epoxides optically active, hiki ke hoʻohana ʻia no ka hoʻonā chiral o nā epoxides a i ʻole ka hoʻomākaukau ʻana o nā chiral diols. Hoʻohana nui ʻia lākou i ka lāʻau lapaʻau a me nā ʻoihana ʻē aʻe. Aia he 3 ʻano o nā huahana epoxide hydrolases (Helu e like me ES-EH-101～ES-EH-103) i hoʻomohala ʻia e SyncoZymes. He mea hana pono ʻo ES-EH e hoʻoulu ai i ka synthesis o nā chiral alcohols ma o ka hydrolysis stereoselective o nā aliphatic a me nā aromatic epoxides.
ʻAno hana catalytic:
Kelepona Paʻalima/Wechat/WhatsApp: +86-13681683526
Leka uila:lchen@syncozymes.com
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ʻO ka dehydrogenase formate (FDH)
E pili ana i ka Formate dehydrogenase
ES-FDH (Formate dehydrogenase): Hoʻoulu ka FDH i ka dehydrogenation o ka ammonium formate e hana i ke kalapona ʻokikene a me ka ammonia, a hoʻemi i ka NAD i NADH me NAD ma ke ʻano he mea loaʻa electron. Hoʻohana pinepine ʻia ka FDH no ka hana hou ʻana o ka coenzyme NADH. Aia he 4 ʻano o nā huahana enzyme FDH (ES-FDH-101~ES-FDH-104) i hoʻomohala ʻia e SyncoZymes, ma waena o ia mau mea ʻo ES-FDH102 ka hana kiʻekiʻe loa a ʻo ia ka FDH i ʻōlelo nui ʻia.
ʻAno hana catalytic:
Kelepona Paʻalima/Wechat/WhatsApp: +86-13681683526
Leka uila:lchen@syncozymes.com
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ʻO ka glucose dehydrogenase (GDH)
E pili ana i ka Glucose dehydrogenase
ES-GDH (Glucose dehydrogenase): Hoʻoulu ʻo GDH i ka dehydrogenation o ka glucose e hana i ka waikawa gluconic (lactone), a hoʻemi iā NAD(P)+ i NAD(P)H, me NAD(P)+ ma ke ʻano he mea loaʻa electron. Hoʻohana pinepine ʻia ʻo GDH no ka hana hou ʻana o ka coenzyme NAD(P)H i nā kahua biocatalysis me nā enzyme nui ʻē aʻe. Aia he 10 ʻano o nā huahana enzyme GDH (ES-GDH-101~ES-GDH-110) i hoʻomohala ʻia e SyncoZymes, a ʻo ES-GDH110 ka mea i loaʻa ka hana kiʻekiʻe loa a ʻo ia ka GDH i ʻōlelo nui ʻia.
ʻAno hana catalytic:
Kelepona Paʻalima/Wechat/WhatsApp: +86-13681683526
Leka uila:lchen@syncozymes.com
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ʻO ka monoamine oxidase (MAO)
E pili ana i ka Monoamine oxidase
ES-MAO (Monoamine oxidase): Hoʻoulu ka MAO i ka deamination oxidative o nā monoamines e hana i ka hydrogen peroxide, ammonia a me nā aldehydes e pili ana. I ke kaʻina hana catalytic, pono ka oxygen ma ke ʻano he oxidant. Aia he 6 ʻano o nā huahana enzyme MAO (Helu e like me ES-MAO-101～ES-MAO-106) i hoʻomohala ʻia e SyncoZymes, hiki ke hoʻohana ʻia i ka deamination oxidative o nā hui monoamine.
ʻAno hana catalytic:
Kelepona Paʻalima/Wechat/WhatsApp: +86-13681683526
Leka uila:lchen@syncozymes.com
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ʻO ka Lactate Dehydrogenase (LDH)
E pili ana i ka Lactate dehydrogenase
Aia kekahi ʻano huahana enzyme LDH (Helu e like me ES-LDH) i hoʻomohala ʻia e SyncoZymes. Hiki i ka LDH ke hoʻoikaika i ka hōʻemi ʻana o ka pyruvate i ka waikawa L-lactic, a i ʻole ka hōʻemi ʻana o nā waikawa α-keto like ʻē aʻe. I ke kaʻina hana o ka catalysis, pono ʻo NADH ma ke ʻano he mea lawe hydrogen.
ʻAno hana catalytic lactate dehydrogenase
Kelepona Paʻalima/Wechat/WhatsApp: +86-13681683526
Leka uila:lchen@syncozymes.com
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ʻImine reductase (IRED)
E pili ana i ka Imine reductase
ES-IRED: He papa o nā enzymes e hoʻoulu ai i ka hōʻemi ʻana o ka pilina C=N i ka pilina CN. No ka enzyme redox ia, me ka coenzyme NADPH no ka lawe ʻana i ka hydrogen. Wahi a ka makemake chiral o nā huahana, hiki ke hoʻokaʻawale ʻia iā R-IRED a me S-IRED. Ua hoʻomohala ʻo Syncozymes i 15 mau imine reductases (numbIRED ES-IRED-101-ES-IRED-115), hiki ke hoʻohana nui ʻia i ka hōʻemi regioselective a me stereoselective o nā imines e hoʻomākaukau i nā amines chiral.
ʻAno hana catalytic:
Kelepona Paʻalima/Wechat/WhatsApp: +86-13681683526
Leka uila:lchen@syncozymes.com
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ʻO ka hoʻemi ʻana o ka nitrile (NRED)
E pili ana i ka Nitrile reductase
Aia he 3 ʻano huahana enzyme NRED (Helu e like me ES-NRED101 ~ ES-NRED103) i hoʻomohala ʻia e SyncoZymes. Hiki iā NRED ke hoʻoikaika i ka hōʻemi ʻana o ka hui nitrile i amine. I ke kaʻina hana o ka catalysis, pono ʻo NADPH ma ke ʻano he mea lawe hydrogen.
ʻAno hana catalytic Nitrile reductase
Kelepona Paʻalima/Wechat/WhatsApp: +86-13681683526
Leka uila:lchen@syncozymes.com
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ʻO ka Leucine Dehydrogenase (LeuDH)
E pili ana i ka Leucine dehydrogenase
Aia kekahi ʻano huahana enzyme LeuDH (Helu e like me ES-LeuDH-101) i hoʻomohala ʻia e SyncoZymes. Hiki iā LeuDH ke hoʻoulu i ka ammoniation reductive o ka 4-methylbutanoic acid (paʻakai) i L-leucine a i ʻole ka oxidation o ka leucine i 4-methylbutanoic acid. Hiki iā ES-LeuDH ke hoʻoulu i ka amination reductive o nā waikawa α-keto me ke ʻano like e hoʻomākaukau i nā derivatives amino acid e pili ana. I ke kaʻina hana o ka catalysis, pono ʻo NADH ma ke ʻano he mea lawe hydrogen.
ʻAno hopena catalytic Leucine dehydrogenase
Kelepona Paʻalima/Wechat/WhatsApp: +86-13681683526
Leka uila:lchen@syncozymes.com
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ʻO ka Threonine deaminase (TDA)
E pili ana i ka Threonine deaminase
ʻO ES-TDA (Threonine deaminase): kahi protein pyridoxal phosphate e hoʻoulu ai i ka deamination o threonine e hana i ka 2-ketobutyric acid a me ka ammonia. Pono ka Pyridoxal 5-phosphate ma ke ʻano he coenzyme i loko o ka ʻōnaehana catalytic. Hoʻokahi wale nō ʻano huahana enzyme TDA (Helu e like me ES-TDA) i hoʻomohala ʻia e SyncoZymes, hiki ke hoʻohana ʻia e hoʻomākaukau i ka 2-ketobutyric acid a i ʻole kona mau derivatives mai threonine.
ʻAno hana catalytic:
Kelepona Paʻalima/Wechat/WhatsApp: +86-13681683526
Leka uila:lchen@syncozymes.com
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ʻAmine Dehydrogenase (AmDH)
E pili ana i ka Amine Dehydrogenase
ʻO ES-AmDH (Amine Dehydrogenase): kahi enzyme hiki ke hoʻoulu i ka ammoniation o ka hui carbonyl a hoʻemi iā ia i ka hui amino. He coenzyme ia e hilinaʻi ana i ka NADH, a hana ʻo NADH ma ke ʻano he mea hoʻoili hydrogen. Aia he 4 ʻano o nā huahana enzyme AmDH (Helu e like me ES-AmDH101～ES-AmDH104) i hoʻomohala ʻia e SyncoZymes, hiki ke hoʻohana ʻia i ka regioselective a i ʻole stereoselective reductive amination o nā aldehydes a me nā ketones.
ʻAno hana catalytic:
Kelepona Paʻalima/Wechat/WhatsApp: +86-13681683526
Leka uila:lchen@syncozymes.com
