Imine reductase (IRED)
ʻO ka wehewehe pōkole:
E pili ana iā Imine reductase
ES-IRED: He papa o nā enzymes nāna e hoʻoemi i ka hoʻopaʻa C=N i ka paʻa CN.No ka redox enzyme, me ka coenzyme NADPH no ka lawe hydrogen.Wahi a ka makemake chiral o nā huahana, hiki ke hoʻokaʻawale ʻia i R-IRED a me S-IRED.Hoʻokumu ʻo Syncozymes i 15 imine reductases (numbIRED ES-IRED-101-ES-IRED-115), hiki ke hoʻohana nui ʻia i ka regioselective a me ka stereoselective reduction o nā imines e hoʻomākaukau ai i nā amine chiral.
ʻAno hoʻopā catalytic:
Mobile/Wechat/WhatsApp: +86-13681683526
E-mail:lchen@syncozymes.com
| Nā Enzymes | Code Huahana | Hōʻike |
| ʻO ka pauka Enzyme | ES-IRED-101~ ES-IRED-114 | he set o 14 Imine Reductase, 50 mg i kēlā me kēia |
| 96-Well Enzyme Screening Kit | ES-IRED-1400 | he set o 14 Imine Reductase, 1 mg i kēlā me kēia |
★ High substrate specificity.
★ Ke koho kiral ikaika.
★ hoʻololi kiʻekiʻe.
★ Liʻiliʻi nā huahana.
★ Nā kūlana hoʻonā haʻahaʻa.
★ Pili kaiapuni.
➢ ʻO ka mea maʻamau, pono e hoʻokomo ʻia ka ʻōnaehana hoʻololi i ka substrate, ka solution buffer, ka enzyme, ka coenzyme, a me ka ʻōnaehana hoʻohou coenzyme.
➢ Pono e aʻo pākahi ʻia nā ʻano ES-IRED a pau e pili ana i nā ʻano hopena maikaʻi loa.
➢ Hiki ke kaohi i ka hana a ES-IRED.Eia naʻe, hiki ke hoʻokuʻu ʻia ka inhibition me ka hoʻohui pū ʻana o ka substrate.
Laʻana 1(Biosynthesis o chiral 2-methyl pyrrolidine)(1):
Laʻana 2(Biosynthesis o ka amine lua)(2):
Ka Laʻana 3 (Hoʻoemi i nā Imine Cyclic)(3):
E mālama i 2 mau makahiki ma lalo o -20 ℃.
Mai hoʻopili i nā kūlana koʻikoʻi e like me: ka wela kiʻekiʻe, ka pH kiʻekiʻe/haʻahaʻa a me ka mea hoʻoheheʻe kūlohelohe kiʻekiʻe.
1. Scheller PN, Fademrecht S, Hofelzer S, et al.ChemBioChem, 2014, 15, 2201-2204.
2. Wetzl D, Gand M, Ross A, et al.ChemCatChem, 2016, 8, 2023-2026.
3. Li H, Luan ZJ, Zheng GW, et al.ʻO Adv.Synth.Catal.2015, 357, 1692-1696.
