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Nā ʻOxynitrilases (HNL)
E pili ana i nā oxynitrilases
ES-HNLs: He papa enzyme e hoʻoikaika ana i ka hoʻohui ʻana o HCN i nā aldehydes (ketones) e loaʻa ai nā ʻano cyanide alcohols ʻano R a i ʻole S, hiki ke hoʻololi maʻalahi ʻia i nā ʻano lāʻau lapaʻau a i ʻole nā mea waena o ka lāʻau lapaʻau ma o ke ʻano kemika.
Aia he 29 ʻano huahana oxynitrilase (Helu e like me ES-HNL-101～ES-HNL-129) i hoʻomohala ʻia e SyncoZymes. He mea hana pono ʻo SZ-HNL no ka regio- a me ka stereo-selective synthesis o (R)-cyanohydrins a i ʻole (S)-cyanohydrins mai nā ʻano aldehydes aromatic, aliphatic a me heterocyclic a i ʻole ketones.
ʻAno hana catalytic:
Kelepona Paʻalima/Wechat/WhatsApp: +86-13681683526
Leka uila:lchen@syncozymes.com
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ʻO ka Nitro reductase (NTR)
E pili ana i ka nitro reductase
ʻO ES-NTRs: He mau flavoenzymes e hoʻoulu ai i ka hoʻemi ʻana o nā hui nitro e pili ana i ka NAD(P)H ma nā hui nitroaromatic a me nitroheterocyclic i nā hydroxylamino a/a i ʻole nā mea loaʻa amino. Hoʻohana nui ʻia lākou i ka synthesis organik o ka hydroxylamine aromatic a me ka amine aromatic, ka mālama ʻana i ka tumor, ka ʻike ʻana i nā mea olaola a me ka hoʻohaʻahaʻa ʻana i nā mea haumia o ke kaiapuni. Aia he 12 mau ʻano huahana Nitro reductase (NTR) (Helu e like me ES-NTR-101~ES-NTR-112) i hoʻomohala ʻia e SyncoZymes.
Kelepona Paʻalima/Wechat/WhatsApp: +86-13681683526
Leka uila:lchen@syncozymes.com
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ʻAldolase (DERA)
ES-DERAs: Hiki ke hoʻoikaika pono i ka hoʻohui stereoselective o nā ketones donor i nā receptor aldehydes. Eia kekahi, hiki ke hana ʻia ka hopena ma ka hopena wai o ka pH neutral me ka ʻole o nā hana pale kūikawā. No ka papa I aldolase lākou, ka mea e hana ai i ke kumu Shiff i ke kaʻina hana catalytic. Hoʻopili ʻia ka substrate me ka hui amino o ka pūnaewele hana e hoʻomaka i ka haki ʻana a me ka hoʻokumu ʻana o ka pilina. ʻO ka ʻokoʻa ma waena o DERAs a me nā aldolases ʻē aʻe, ʻo ia nā substrates a lākou e catalyze ai he aldehydes a hiki ke hana i ka condensation aldehydes mau.
Kelepona Paʻalima/Wechat/WhatsApp: +86-13681683526
Leka uila:lchen@syncozymes.com
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ʻO ka Cytochrome P450 monooxygenase (CYP)
E pili ana iā CYP
ES-CYPs: He papa o nā enzymes redox me mercaptan-heme ma ke kikowaena hana e hoʻoulu ai i ka hoʻoili oxygen. He mau oxygenases hope lākou a pono i ka heme e hoʻoulu i ka oxygen.
Hoʻoulu ka Cytochrome P450 monooxygenase i ka oxidation, epoxidation a me ka hydroxylation o ka alkyl, hydroxylation a me ka oxidation o ka ammonia, oxidation o ka sulfur, dealkylation (oxygen, sulfur, ammonia), oxidative dehydrogenation, deamination a me ka dehalogenation.
Aia he 8 ʻano o nā huahana cytochrome P450 monooxygenase (Helu e like me ES-CYP-101～ES-CYP-108) i hoʻomohala ʻia e SyncoZymes.Kelepona Paʻalima/Wechat/WhatsApp: +86-13681683526
Leka uila:lchen@syncozymes.com
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ʻO ka ʻona ʻokikene (AOX)
E pili ana i ka waiʻona oxidase
ES-AOXs: Hiki i kēia mau enzymes ke hoʻoulu i ka oxidation o nā fatty alcohols a i ʻole aryl-alcohols e hana i nā aldehydes. Hoʻohana lākou i ka oxygen molekala akā ʻaʻole pono i kahi cofactor i hoʻohui ʻia mai waho, a hana ʻia ka hydrogen peroxide.
Aia he 6 ʻano huahana ʻona oxidases (Helu e like me ES-AOX-101~ES-AOX-106) i hoʻomohala ʻia e SyncoZymes. Makemake ʻo ES-AOX101 a me ES-AOX102 i nā substrates ʻona aliphatic, makemake ʻo ES-AOX103~ ES-AOX105 i nā substrates ʻona ʻala, a ʻo ES-AOX106 ka cholesterol oxidase. He mea hana pono ʻo SZ-AOX e hoʻoulu i ka oxidation o nā ʻona momona a i ʻole nā aryl-alcohols e hana i nā aldehydes.
ʻAno hana catalytic:
Kelepona Paʻalima/Wechat/WhatsApp: +86-13681683526
Leka uila:lchen@syncozymes.com
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ʻO ka D-Amino acid dehydrogenase (D-AADH)
E pili ana i ka D-Amino acid dehydrogenase
ʻO ES-D-AADH (D-Amino acid dehydrogenase): kahi enzyme e hiki ke hoʻemi i ka 2-keto acid i loko o ka D-amino acid e pili ana. Pono ka hopena i ka NADP(H) a me ka mea hāʻawi ammonia inorganic (e like me ka ammonia a i ʻole ka ammonium ion). Aia he 17 ʻano o nā D-amino acid dehydrogenases (Helu e like me ES-DAADH-101 ~ ES-DAADH-117) i hoʻomohala ʻia e SyncoZymes.
ʻAno hana catalytic:
Kelepona Paʻalima/Wechat/WhatsApp: +86-13681683526
Leka uila:lchen@syncozymes.com
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ʻEsterase a me Lipase (PLE a me CALB)
E pili ana iā Esterase & Lipase
ES-PLEs: He papa o nā hydrolases e hoʻoulu ai i ka hoʻokumu ʻana a me ka haki ʻana o nā pilina ester. Hiki iā lākou ke komo i nā ʻano hopena biochemical he nui, e like me ka esterification, transesterification a me ka hydrolysis. Hoʻohana nui ʻia lākou ma nā ʻano he nui e like me ka hana ʻana i ka meaʻai, ka ʻoihana kemika, ka biomedicine, ka lāʻau lapaʻau chiral a me ka mālama ʻana i ke kaiapuni.
Kelepona Paʻalima/Wechat/WhatsApp: +86-13681683526
Leka uila:lchen@syncozymes.com
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ʻEpoxide hydrolase (EH)
E pili ana i ka epoxide hydrolase
ʻO EH ka ether hydrolase e hoʻoulu ai i ka hydrolysis stereoselective o nā racemic epoxides e hana i ka 1, 2-diol a me nā epoxides optically active, hiki ke hoʻohana ʻia no ka hoʻonā chiral o nā epoxides a i ʻole ka hoʻomākaukau ʻana o nā chiral diols. Hoʻohana nui ʻia lākou i ka lāʻau lapaʻau a me nā ʻoihana ʻē aʻe. Aia he 3 ʻano o nā huahana epoxide hydrolases (Helu e like me ES-EH-101～ES-EH-103) i hoʻomohala ʻia e SyncoZymes. He mea hana pono ʻo ES-EH e hoʻoulu ai i ka synthesis o nā chiral alcohols ma o ka hydrolysis stereoselective o nā aliphatic a me nā aromatic epoxides.
ʻAno hana catalytic:
Kelepona Paʻalima/Wechat/WhatsApp: +86-13681683526
Leka uila:lchen@syncozymes.com
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ʻO ka dehydrogenase formate (FDH)
E pili ana i ka Formate dehydrogenase
ES-FDH (Formate dehydrogenase): Hoʻoulu ka FDH i ka dehydrogenation o ka ammonium formate e hana i ke kalapona ʻokikene a me ka ammonia, a hoʻemi i ka NAD i NADH me NAD ma ke ʻano he mea loaʻa electron. Hoʻohana pinepine ʻia ka FDH no ka hana hou ʻana o ka coenzyme NADH. Aia he 4 ʻano o nā huahana enzyme FDH (ES-FDH-101~ES-FDH-104) i hoʻomohala ʻia e SyncoZymes, ma waena o ia mau mea ʻo ES-FDH102 ka hana kiʻekiʻe loa a ʻo ia ka FDH i ʻōlelo nui ʻia.
ʻAno hana catalytic:
Kelepona Paʻalima/Wechat/WhatsApp: +86-13681683526
Leka uila:lchen@syncozymes.com
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ʻO ka glucose dehydrogenase (GDH)
E pili ana i ka Glucose dehydrogenase
ES-GDH (Glucose dehydrogenase): Hoʻoulu ʻo GDH i ka dehydrogenation o ka glucose e hana i ka waikawa gluconic (lactone), a hoʻemi iā NAD(P)+ i NAD(P)H, me NAD(P)+ ma ke ʻano he mea loaʻa electron. Hoʻohana pinepine ʻia ʻo GDH no ka hana hou ʻana o ka coenzyme NAD(P)H i nā kahua biocatalysis me nā enzyme nui ʻē aʻe. Aia he 10 ʻano o nā huahana enzyme GDH (ES-GDH-101~ES-GDH-110) i hoʻomohala ʻia e SyncoZymes, a ʻo ES-GDH110 ka mea i loaʻa ka hana kiʻekiʻe loa a ʻo ia ka GDH i ʻōlelo nui ʻia.
ʻAno hana catalytic:
Kelepona Paʻalima/Wechat/WhatsApp: +86-13681683526
Leka uila:lchen@syncozymes.com
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ʻO ka monoamine oxidase (MAO)
E pili ana i ka Monoamine oxidase
ES-MAO (Monoamine oxidase): Hoʻoulu ka MAO i ka deamination oxidative o nā monoamines e hana i ka hydrogen peroxide, ammonia a me nā aldehydes e pili ana. I ke kaʻina hana catalytic, pono ka oxygen ma ke ʻano he oxidant. Aia he 6 ʻano o nā huahana enzyme MAO (Helu e like me ES-MAO-101～ES-MAO-106) i hoʻomohala ʻia e SyncoZymes, hiki ke hoʻohana ʻia i ka deamination oxidative o nā hui monoamine.
ʻAno hana catalytic:
Kelepona Paʻalima/Wechat/WhatsApp: +86-13681683526
Leka uila:lchen@syncozymes.com
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ʻO ka Lactate Dehydrogenase (LDH)
E pili ana i ka Lactate dehydrogenase
Aia kekahi ʻano huahana enzyme LDH (Helu e like me ES-LDH) i hoʻomohala ʻia e SyncoZymes. Hiki i ka LDH ke hoʻoikaika i ka hōʻemi ʻana o ka pyruvate i ka waikawa L-lactic, a i ʻole ka hōʻemi ʻana o nā waikawa α-keto like ʻē aʻe. I ke kaʻina hana o ka catalysis, pono ʻo NADH ma ke ʻano he mea lawe hydrogen.
ʻAno hana catalytic lactate dehydrogenase
Kelepona Paʻalima/Wechat/WhatsApp: +86-13681683526
Leka uila:lchen@syncozymes.com
