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ʻO ka Transaldolase (TAL)
E pili ana iā Transaldolase
ʻO ES-TAL (Transaldolase): pili nui i nā threonine transaldolases, hiki ke hoʻoulu i ka hopena e synthesize i nā β-hydroxyphenylalanine derivatives me nā threonine a me nā benzaldehyde derivatives. ʻO TAL ka enzyme e hilinaʻi ana iā PLP. Hoʻokahi wale nō ʻano huahana enzyme TAL (Helu e like me ES-TAL101) i hoʻomohala ʻia e SyncoZymes, hiki ke hoʻohana ʻia no ka synthesis o β-hydroxyphenylalanine a me kāna mau derivatives.
ʻAno hana catalytic:
Kelepona Paʻalima/Wechat/WhatsApp: +86-13681683526
Leka uila:lchen@syncozymes.com
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Ketoreductase (KRED)
E pili ana iā Ketoreductase
Nā ʻenzymes: He mau mea hoʻoulu olaola macromolecular, ʻo ka hapa nui o nā enzymes he mau protein.
ʻO Ketoreductase: Ua kapa ʻia hoʻi ʻo "Carbonyl reductase", he mau enzymes e hoʻoulu ai i ka hopena redox hiki ke hoʻohuli ʻia ma waena o nā aldehydes / ketones a me nā alcohols, a pono nā coenzymes ma ke ʻano he mea hoʻoili H e like me NADH a i ʻole NADPH. ʻEkolu mau māhele nui o KRED: Short-chain Dehydrogenase / Reductases (SDRs), Medium-chain Dehydrogenases / Reductases (MDRs), a me Aldo-KetoReductases (AKRs). Ua like nā hana catalytic o nā mea ʻekolu, akā ʻokoʻa loa ke ʻano a me nā waiwai.
Kelepona Paʻalima/Wechat/WhatsApp: +86-13681683526
Leka uila:lchen@syncozymes.com
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ʻO ka Transaminase (ATA)
E pili ana i ka transaminase
ʻO ATA mai SyncoZymes: Aia he 66 mau ʻano huahana enzyme ATA (Helu e like me ES-ATA-101 ~ ES-ATA-166) i hoʻomohala ʻia e SyncoZymes. He mea hana pono ʻo SZ-ATA e hoʻoulu ai i ka synthesis regio- a me stereoselective o nā amines chiral, nā waikawa amino a me kā lākou mau derivatives mai nā ʻano ketoacids aliphatic a me aromatic, aldehydes, ketones a me ketoses.
Kelepona Paʻalima/Wechat/WhatsApp: +86-13681683526
Leka uila:lchen@syncozymes.com
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Nitrilase (NIT)
E pili ana iā Nitrilase
ES-NITs: Hoʻololi pololei i ka hui cyanide i ka hui carboxyl, e hoʻomākaukau i ka waikawa carboxylic, i hoʻohana nui ʻia i ka lāʻau lapaʻau, ka palekana o ke kaiapuni, ka ʻoihana kemika, ka mea hoʻohui meaʻai, ka lole, ka hana mahiʻai a me nā ʻoihana ʻē aʻe.
Aia he 40 ʻano o nā huahana Nitrilase (NIT) (Helu e like me ES-NIT-101 ~ ES-NIT-140) i hoʻomohala ʻia e SyncoZymes. He mea hana pono ʻo ES-NIT e hoʻoulu ai i ka synthesis o nā waikawa carboxylic chiral ma o ka regio- a me ka stereoselective hydrolysis o kahi ākea o nā nitriles aliphatic a me nā aromatic.ʻAno hana catalytic:
Kelepona Paʻalima/Wechat/WhatsApp: +86-13681683526
Leka uila:lchen@syncozymes.com
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ʻO ka nitrile hydratase (NHT)
E pili ana i nā ES-NHT
ʻO ES-NHTs: kahi papa o ka metalloenzyme, kahi e hoʻokahe koho ai i nā nitriles i loko o ka amide mua e pili ana. Hoʻohana nui ʻia lākou ʻaʻole wale no ka synthesis o nā waikawa amino, amides, nā waikawa carboxylic a me kā lākou derivatives, akā no ka hoʻomākaukau ʻana i nā lāʻau chiral. Aia he 24 mau ʻano nitrile hydratases i hoʻomohala ʻia e SyncoZymes (Helu e like me ES-NHT-101～ES-NHT-124).
ʻAno hana catalytic:
Kelepona Paʻalima/Wechat/WhatsApp: +86-13681683526
Leka uila:lchen@syncozymes.com
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ʻAmidase (AMD)
AMD mai SyncoZymes: Aia he 19 mau ʻano huahana enzyme AMD (Helu e like me ES-AMD-101 ~ ES-AMD-119) i hoʻomohala ʻia e SyncoZymes. He mea hana pono ʻo SZ-AMD e hoʻoulu ai i ka synthesis regio- a me stereoselective o nā waikawa carboxylic chiral a me kā lākou mau derivatives mai nā ʻano aliphatic a me nā aromatic amides.
Kelepona Paʻalima/Wechat/WhatsApp: +86-13681683526
Leka uila:lchen@syncozymes.com
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ʻEne reductase (ERED)
E pili ana i ka ene reductase
ʻO ES-EREDs: No ka ʻohana o nā enzyme melemele kahiko e hōʻemi koho ana iā C=C i loko o nā hui α, β-unsaturated me nā hui electron-absorbing. Hoʻohana nui ʻia lākou i ke aʻo ʻana i nā derivatives amino acid, nā mea bioactive, nā mea waena lāʻau lapaʻau, nā mea ʻala a me nā poloka chiral.
Kelepona Paʻalima/Wechat/WhatsApp: +86-13681683526
Leka uila:lchen@syncozymes.com
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Nā ʻOxynitrilases (HNL)
E pili ana i nā oxynitrilases
ES-HNLs: He papa enzyme e hoʻoikaika ana i ka hoʻohui ʻana o HCN i nā aldehydes (ketones) e loaʻa ai nā ʻano cyanide alcohols ʻano R a i ʻole S, hiki ke hoʻololi maʻalahi ʻia i nā ʻano lāʻau lapaʻau a i ʻole nā mea waena o ka lāʻau lapaʻau ma o ke ʻano kemika.
Aia he 29 ʻano huahana oxynitrilase (Helu e like me ES-HNL-101～ES-HNL-129) i hoʻomohala ʻia e SyncoZymes. He mea hana pono ʻo SZ-HNL no ka regio- a me ka stereo-selective synthesis o (R)-cyanohydrins a i ʻole (S)-cyanohydrins mai nā ʻano aldehydes aromatic, aliphatic a me heterocyclic a i ʻole ketones.
ʻAno hana catalytic:
Kelepona Paʻalima/Wechat/WhatsApp: +86-13681683526
Leka uila:lchen@syncozymes.com
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ʻO ka Nitro reductase (NTR)
E pili ana i ka nitro reductase
ʻO ES-NTRs: He mau flavoenzymes e hoʻoulu ai i ka hoʻemi ʻana o nā hui nitro e pili ana i ka NAD(P)H ma nā hui nitroaromatic a me nitroheterocyclic i nā hydroxylamino a/a i ʻole nā mea loaʻa amino. Hoʻohana nui ʻia lākou i ka synthesis organik o ka hydroxylamine aromatic a me ka amine aromatic, ka mālama ʻana i ka tumor, ka ʻike ʻana i nā mea olaola a me ka hoʻohaʻahaʻa ʻana i nā mea haumia o ke kaiapuni. Aia he 12 mau ʻano huahana Nitro reductase (NTR) (Helu e like me ES-NTR-101~ES-NTR-112) i hoʻomohala ʻia e SyncoZymes.
Kelepona Paʻalima/Wechat/WhatsApp: +86-13681683526
Leka uila:lchen@syncozymes.com
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ʻAldolase (DERA)
ES-DERAs: Hiki ke hoʻoikaika pono i ka hoʻohui stereoselective o nā ketones donor i nā receptor aldehydes. Eia kekahi, hiki ke hana ʻia ka hopena ma ka hopena wai o ka pH neutral me ka ʻole o nā hana pale kūikawā. No ka papa I aldolase lākou, ka mea e hana ai i ke kumu Shiff i ke kaʻina hana catalytic. Hoʻopili ʻia ka substrate me ka hui amino o ka pūnaewele hana e hoʻomaka i ka haki ʻana a me ka hoʻokumu ʻana o ka pilina. ʻO ka ʻokoʻa ma waena o DERAs a me nā aldolases ʻē aʻe, ʻo ia nā substrates a lākou e catalyze ai he aldehydes a hiki ke hana i ka condensation aldehydes mau.
Kelepona Paʻalima/Wechat/WhatsApp: +86-13681683526
Leka uila:lchen@syncozymes.com
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ʻO ka Cytochrome P450 monooxygenase (CYP)
E pili ana iā CYP
ES-CYPs: He papa o nā enzymes redox me mercaptan-heme ma ke kikowaena hana e hoʻoulu ai i ka hoʻoili oxygen. He mau oxygenases hope lākou a pono i ka heme e hoʻoulu i ka oxygen.
Hoʻoulu ka Cytochrome P450 monooxygenase i ka oxidation, epoxidation a me ka hydroxylation o ka alkyl, hydroxylation a me ka oxidation o ka ammonia, oxidation o ka sulfur, dealkylation (oxygen, sulfur, ammonia), oxidative dehydrogenation, deamination a me ka dehalogenation.
Aia he 8 ʻano o nā huahana cytochrome P450 monooxygenase (Helu e like me ES-CYP-101～ES-CYP-108) i hoʻomohala ʻia e SyncoZymes.Kelepona Paʻalima/Wechat/WhatsApp: +86-13681683526
Leka uila:lchen@syncozymes.com
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ʻO ka ʻona ʻokikene (AOX)
E pili ana i ka waiʻona oxidase
ES-AOXs: Hiki i kēia mau enzymes ke hoʻoulu i ka oxidation o nā fatty alcohols a i ʻole aryl-alcohols e hana i nā aldehydes. Hoʻohana lākou i ka oxygen molekala akā ʻaʻole pono i kahi cofactor i hoʻohui ʻia mai waho, a hana ʻia ka hydrogen peroxide.
Aia he 6 ʻano huahana ʻona oxidases (Helu e like me ES-AOX-101~ES-AOX-106) i hoʻomohala ʻia e SyncoZymes. Makemake ʻo ES-AOX101 a me ES-AOX102 i nā substrates ʻona aliphatic, makemake ʻo ES-AOX103~ ES-AOX105 i nā substrates ʻona ʻala, a ʻo ES-AOX106 ka cholesterol oxidase. He mea hana pono ʻo SZ-AOX e hoʻoulu i ka oxidation o nā ʻona momona a i ʻole nā aryl-alcohols e hana i nā aldehydes.
ʻAno hana catalytic:
Kelepona Paʻalima/Wechat/WhatsApp: +86-13681683526
Leka uila:lchen@syncozymes.com
