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Ketoreductase (KRED)
E pili ana iā Ketoreductase
Nā Enzymes: He macromolecular biological catalysts, ʻo ka hapa nui o nā enzyme he protein.
Ketoreductase: Ua kapa ʻia hoʻi ʻo "Carbonyl reductase", he mau enzyme e hoʻolalelale i ka hopena redox reversible ma waena o nā aldehydes / ketones a me nā ʻona, a pono nā coenzymes e like me ka H transmitter e like me NADH a i ʻole NADPH.ʻEkolu mau ʻano nui o KRED: Short-chain Dehydrogenase / Reductases (SDRs), Medium-chain Dehydrogenases / Reductases (MDRs), a me Aldo-KetoReductases (AKRs).Ua like nā hana catalytic o nā ʻekolu, akā ʻokoʻa ke ʻano a me nā waiwai.
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E-Mail:lchen@syncozymes.com
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Transaminase (ATA)
E pili ana i ka transaminase
ATA mai SyncoZymes: Aia he 66 ʻano huahana enzyme ATA (Helu e like me ES-ATA-101~ES-ATA-166) i hoʻomohala ʻia e SyncoZymes.ʻO SZ-ATA kahi mea hana pono e hoʻopili i ka regio- a me stereoselective synthesis o chiral amines, amino acids a me kā lākou derivatives mai nā ʻano ketoacids aliphatic a me nā mea ʻala, nā aldehydes, nā ketones a me nā ketoses.
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E-Mail:lchen@syncozymes.com
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Nitrilase (NIT)
No Nitrilase
ES-NITs: Hoʻololi pololei i ka hui cyanide i ka hui carboxyl, e hoʻomākaukau ai i ka waikawa carboxylic, i hoʻohana nui ʻia i ka lāʻau lapaʻau, ka mālama ʻana i ke kaiapuni, ʻoihana kemika, mea hoʻohui meaʻai, textile, hana mahiʻai a me nā māla ʻē aʻe.
He 40 mau ʻano huahana Nitrilase(NIT) (Helu e like me ES-NIT-101~ES-NIT-140) i hoʻomohala ʻia e SyncoZymes.He mea hana pono ka ES-NIT no ka hoʻopili ʻana i ka synthesis o nā waikawa carboxylic chiral ma o ka regio- a me stereoselective hydrolysis o kahi ākea o nā aliphatic a me nā nitriles aromatic.ʻAno hoʻopā catalytic:
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E-Mail:lchen@syncozymes.com
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Nitrile hydratase (NHT)
E pili ana i nā ES-NHT
Nā ES-NHTs: he papa o ka metalloenzyme, e hoʻomaʻemaʻe i nā nitriles i loko o ka amide kumu.Hoʻohana nui ʻia lākou ʻaʻole wale no ka synthesis o nā amino acids, amides, carboxylic acids a me kā lākou derivatives, akā no ka hoʻomākaukau ʻana i nā lāʻau chiral.Aia he 24 mau ʻano nitrile hydratases i hoʻomohala ʻia e SyncoZymes (Helu e like me ES-NHT-101～ES-NHT-124).
ʻAno hoʻopā catalytic:
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E-Mail:lchen@syncozymes.com
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Amidase (AMD)
AMD mai SyncoZymes: Aia he 19 mau ʻano huahana enzyme AMD (Helu e like me ES-AMD-101~ES-AMD-119) i hoʻomohala ʻia e SyncoZymes.He mea hana pono ka SZ-AMD no ka hoʻopili ʻana i ka regio- a me ka stereoselective synthesis o nā ʻakika carboxylic chiral a me kā lākou mau mea i loaʻa mai nā ʻano aliphatic a me nā amides aromatic.
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E-Mail:lchen@syncozymes.com
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Ene reductase (ERED)
E pili ana i ka ene reductase
Nā ES-ERED: No ka ʻohana o nā enzyme melemele kahiko e hōʻemi i ka C=C i loko o nā pūhui α, β -unsaturated me nā pūʻulu hoʻopaʻa electron.Hoʻohana nui ʻia lākou i ke aʻo ʻana i nā derivatives amino acid, bioactive substances, pharmaceutical intermediates, mea ʻala a me nā poloka chiral.
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E-Mail:lchen@syncozymes.com
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Oxynitrilase (HNL)
E pili ana i nā oxynitrilase
ES-HNLs: He enzyme papa e hoʻopololei ana i ka hoʻohui ʻana o HCN i nā aldehydes (ketones) no ka loaʻa ʻana o nā ʻona ʻona cyanide ʻano R a i ʻole S, hiki ke hoʻololi maʻalahi i nā ʻano lāʻau lapaʻau a i ʻole nā lāʻau waena ma o ke ʻano kemika.
Aia he 29 ʻano huahana oxynitrilase (Helu e like me ES-HNL-101～ES-HNL-129) i hoʻomohala ʻia e SyncoZymes.He mea hana pono ka SZ-HNL i ka regio- a me ka stereo- selective synthesis o (R) -cyanohydrins a i ʻole (S) -cyanohydrins mai nā ʻano mea ʻala like ʻole, aliphatic a heterocyclic aldehydes a i ʻole ketones.
ʻAno hoʻopā catalytic:
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E-Mail:lchen@syncozymes.com
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Nitro reductase (NTR)
E pili ana i ka nitro reductase
ES-NTRs: He mau flavoenzymes ka mea e hoʻoemi i ka NAD(P)H i hilinaʻi ʻia o nā pūʻulu nitro ma nā pūhui nitroaromatic a me nitroheterocyclic i ka hydroxylamino a/a i nā derivatives amino.Hoʻohana nui ʻia lākou i ka synthesis organik o ka aromatic hydroxylamine a me ka aromatic amine, ka maʻi tumora, ka ʻike biological a me ka hoʻohaʻahaʻa ʻana i nā mea haumia kaiapuni.Aia he 12 ʻano o nā huahana Nitro reductase (NTR) (Helu e like me ES-NTR-101~ES-NTR-112) i hoʻomohala ʻia e SyncoZymes.
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E-Mail:lchen@syncozymes.com
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Aldolase (DERA)
Nā ES-DERA: Hiki ke hoʻopili pono i ka hoʻohui stereoselective o nā ketone hāʻawi i nā aldehydes i loaʻa.Eia kekahi, hiki ke hana ʻia ka hopena i loko o ka wai wai o ka pH neutral me ka ʻole o nā hana pale kūikawā.Aia lākou i ka papa I aldolase, ka mea i hoʻokumu i ke kumu Shiff i ka hana catalytic.Hoʻopili paʻa ʻia ka substrate me ka hui amino o ka pae hana e hoʻomaka ai i ka haki ʻana a me ka hoʻokumu ʻana o ka paʻa.ʻO ka ʻokoʻa ma waena o nā DERA a me nā aldolase ʻē aʻe, ʻo nā substrates a lākou e hoʻopaʻa ai he aldehydes a hiki ke hoʻomau i ka condensation aldehydes.
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E-Mail:lchen@syncozymes.com
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Cytochrome P450 monooxygenase (CYP)
E pili ana iā CYP
ES-CYPs: He papa o nā enzymes redox me mercaptan-heme ma ke ʻano he kikowaena hana e hoʻoikaika i ka hoʻoili oxygen.He mau oxygenases hope lākou a pono lākou i ka heme e hoʻāla ai i ka oxygen.
Cytochrome P450 monooxygenase catalyze i ka oxidation, epoxidation a me ka hydroxylation o alkyl, hydroxylation a me ka oxidation o ka amonia, oxidation o sulfur, dealkylation (oxygen, sulfur, amonia), oxidative dehydrogenation, deamination a me ka dehalogenation.
He 8 mau ʻano huahana cytochrome P450 monooxygenase (Helu e like me ES-CYP-101～ES-CYP-108) i hoʻomohala ʻia e SyncoZymes.Mobile/Wechat/WhatsApp: +86-13681683526
E-Mail:lchen@syncozymes.com
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Alcohol oxidase (AOX)
E pili ana i ka waiʻona oxidase
ES-AOXs: Hiki i kēia mau enzymes ke hoʻopololei i ka hoʻoheheʻe ʻia o nā momona momona a i ʻole nā aryl-alcohols e hana i nā aldehydes.Hoʻohana lākou i ka oxygen molekula akā ʻaʻole koi i kahi cofactor i hoʻohui ʻia i waho, a hana ʻia ka hydrogen peroxide.
Aia he 6 mau ʻano huahana oxidases alcohol (Helu e like me ES-AOX-101~ES-AOX-106) i hoʻomohala ʻia e SyncoZymes.Makemake ʻo ES-AOX101 a me ES-AOX102 i nā substrate waiʻona aliphatic, ʻo ES-AOX103~ ES-AOX105 makemake i nā substrate waiʻona ʻala, a ʻo ES-AOX106 ka cholesterol oxidase.He mea hana pono ka SZ-AOX no ka hoʻopaʻa ʻana i nā ʻona momona a i ʻole nā aryl-alcohols e hana i nā aldehydes.
ʻAno hoʻopā catalytic:
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E-Mail:lchen@syncozymes.com
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D-Amino acid dehydrogenase (D-AADH)
E pili ana i ka D-Amino acid dehydrogenase
ES-D-AADH (D-Amino acid dehydrogenase): he enzyme hiki ke hoʻemi i ka waika 2-keto i loko o ka waika D-amino like.Pono ka hopena i ka NADP(H) a me ka mea hāʻawi ammonia inorganic (e like me ka ammonia a i ʻole ammonium ion).He 17 mau ʻano D-amino acid dehydrogenases (Helu e like me ES-DAADH-101~ ES-DAADH-117) i hoʻomohala ʻia e SyncoZymes.
ʻAno hoʻopā catalytic:
Mobile/Wechat/WhatsApp: +86-13681683526
E-Mail:lchen@syncozymes.com
